The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

被引：1739

作者：

Merad, Miriam ^{[1
,2
,3
]}

Sathe, Priyanka ^{[1
,2
]}

Helft, Julie ^{[1
,2
]}

Miller, Jennifer ^{[1
,2
]}

Mortha, Arthur ^{[1
,2
]}

机构：

[1] Mt Sinai Sch Med, Dept Oncol Sci, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Inst Immunol, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY 10029 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 | 2013年 / 31卷

关键词：

dendritic cells; plasmacytoid dendritic cells; inflammation; innate immunity; adaptive immunity; MHC CLASS-I; HEMATOPOIETIC PROGENITOR CELLS; PERIPHERAL LYMPHOID ORGANS; COLONY-STIMULATING FACTOR; REGULATORY T-CELLS; EPIDERMAL LANGERHANS CELLS; ANTIGEN CROSS-PRESENTATION; LYMPHOTOXIN-BETA-RECEPTOR; TRANSCRIPTION FACTOR E2-2; LEUKEMIA-LIKE SYNDROME;

D O I：

10.1146/annurev-immunol-020711-074950

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) form a remarkable cellular network that shapes adaptive immune responses according to peripheral cues. After four decades of research, we now know that DCs arise from a hematopoietic lineage distinct from other leukocytes, establishing the DC system as a unique hematopoietic branch. Recent work has also established that tissue DCs consist of developmentally and functionally distinct subsets that differentially regulate T lymphocyte function. This review discusses major advances in our understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.

引用

页码：563 / 604

页数：42

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