DECREASED HEART RATE VARIABILITY IS ASSOCIATED WITH INCREASED TRANSCRANIAL DOPPLER VELOCITIES IN CHILDREN WITH SICKLE CELL DISEASE

Objective: To explore the relationship between 24-hour blood pressure (BP) variability, heart rate (HR) variability, and transcranial Doppler velocity (TCDV) in a cohort of pediatric sickle cell disease (SCD) patients. Design, Setting, and Participants: This is a retrospective study of 11 children aged 818 years with SCD who previously underwent 24-hour ambulatory BP monitoring and TCDV measurements. Interventions: Medical records were reviewed for TCDV and 24-hour ABP data. TCDV in the right and left middle cerebral artery were examined, and the highest velocity was recorded. HR and BP standard deviations were used as markers of variability. The relationships between daytime, nighttime, and 24-hour blood pressures and heart rate variability were determined. Results: Mean age, body mass index and hemoglobin levels were 11.2 +/- 3.0 years, 18.7 +/- 3.4 kg/m(2), and 9.1 +/- 1.7 g/dL, respectively. Median transcranial Doppler velocity was 136cm/s (125-142). Decreased day, night, and 24-hour heart rate variability were significantly associated with increased transcranial Doppler velocity (R=-.69, P=.02; R=-.82 P=.002; R=-.66, P=.03, respectively). BP variability did not correlate with TCDV. Nighttime BP indexes were higher than daytime. Conclusions: In this small cohort, decreased heart rate variability assessed by the standard deviation of HR was associated with increased transcranial Doppler velocities in children with SCD. No correlation between measurements of BP variability and TCDV was found. Our study provides new information on heart rate and blood pressure variability and TCDV; a surrogate marker of stroke risk in sickle cell disease. Larger multicenter studies are needed to confirm our findings.