Innate sensing of bacterial cyclic dinucleotides: more than just STING

被引：24
作者：
Bowie, Andrew G. [1 ]
机构：
[1] Univ Dublin Trinity Coll, Trin Biomed Sci Inst, Sch Biochem & Immunol, Dublin 2, Ireland
来源：
NATURE IMMUNOLOGY | 2012年 / 13卷 / 12期
关键词：
DI-GMP;
D O I：
10.1038/ni.2469
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Bacterial cyclic dinucleotides are recognized by the innate immune system, and this leads to the induction of type I interferons. The mammalian helicase DDX41 directly binds cyclic dinucleotides and mediates the signaling pathway to the induction of type I interferons.
引用
收藏
页码：1137 / 1139
页数：4
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