Identification of a methioninase inhibitor, myrsinoic acid B, from Myrsine seguinii Lev., and its inhibitory activities

被引：13
|
作者：
Ito, Satomi [1 ]
Narise, Atsushi [1 ]
Shimura, Susumu [1 ]
机构：
[1] Lotte Co Ltd, Cent Lab, Minami Ku, Saitama 3368601, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 09期
关键词：
methyl mercaptan; methioninase; myrsinoic acid B; Myrsine seguinii; taimin-tachibana;
D O I：
10.1271/bbb.80045
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A methioninase inhibitor from Myrsine seguinii was purified and identified as myrsinoic acid B. Its inhibitory activities as to crude methioninase from periodontal bacteria such as Fusobacterium nucleatum, Porphyromonas gingivalis, and Treponema denticola were determined. The IC50 values were 10.5, 82.4, and 30.3 mu M respectively.
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收藏
页码：2411 / 2414
页数：4
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