Direct Acyloxylation of C(sp2)-H and C(sp2)-X (X = Cl, Br) Bonds in Aromatic Amides Using Copper Bromide and 2-(4,5-Dihydro-oxazol-2-yl)-phenylamine

被引：16

作者：

Li, Gang-Jian ^{[1
]}

Pan, You-Lu ^{[1
]}

Liu, Yan-Ling ^{[1
]}

Xu, Hai-Feng ^{[1
]}

Chen, Jian-Zhong ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, 866 Yuhangtang Rd, Hangzhou, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 06期

基金：

中国国家自然科学基金;

关键词：

CATALYZED ACYLOXYLATION; C(SP(3))-H; ARENES; FUNCTIONALIZATION; (HETERO)ARENES; AMINATION; ARYLATION;

D O I：

10.1021/acs.orglett.9b00306

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here we reported a method for Cu2+-catalyzed ortho-acyloxylation of either the C(sp(2))-H or C(sp(2))-X (X = Cl, Br) bond of aromatic amides with carboxylic acid, especially olefine acids, to obtain corresponding products in good yields up to 91%. The catalyst CuBr2 is cheap and stable to conserve in comparison with other metals, like Rh, Pd, Ru, and Cu+. This simple procedure is applicable for wide substrate scope and various functional groups to produce carboxylic esters without any additives or ligands.

引用

页码：1740 / 1743

页数：4

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