Jumping into Metastable 1:1 Urea-Succinic Acid Cocrystal Zone by Freeze-Drying

被引：9
|
作者：
Yu, Qiushuo [1 ]
Pu, Jiaojiao [1 ]
Qi, Min [1 ]
Yang, Huaiyu [2 ]
机构：
[1] Northwest Univ, Sch Chem Engn, Xian 710069, Shaanxi, Peoples R China
[2] Loughborough Univ, Dept Chem Engn, Loughborough LE11 3TU, Leics, England
来源：
CRYSTAL GROWTH & DESIGN | 2019年 / 19卷 / 03期
基金：
美国国家科学基金会;
关键词：
PHASE; CRYSTALLIZATION; MECHANOCHEMISTRY; MECHANISMS; CHEMISTRY; SYSTEMS;
D O I：
10.1021/acs.cgd.8b01778
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Aqueous solutions with molar ratios between urea and succinic acid from 0.3:1 to 3:1 were evaporated at room temperature, and products were pure or mixtures of stable 2:1 urea-succinic acid cocrystals, urea or succinic acid. By freeze-drying, metastable 1:1 urea-succinic acid cocrystal formed. The different mixtures of the 1:1 cocrystals reveal several "hidden" metastable zones in a ternary phase diagram of the 2:1 cocrystal. The formation of the 1:1 cocrystal indicated that the solution composition points in the phase diagram "jump" over the stable zone into the metastable zones.
引用
收藏
页码：1505 / 1508
页数：4
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