Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse

被引：34
作者：
Flock, M.
Karlstrom, A.
Lannergard, J.
Guss, B.
Flock, J. -I.
机构：
[1] Karolinska Inst, Microbiol & Tumor Biol Ctr, SE-17177 Stockholm, Sweden
[2] Huddinge Univ Hosp, Karolinska Inst, Dept Lab Med, SE-14186 Stockholm, Sweden
[3] Swedish Univ Agr Sci, Dept Microbiol, SE-75007 Uppsala, Sweden
来源：
VACCINE | 2006年 / 24卷 / 19期
关键词：
Streptococcus equi; strangles; vaccination; extra cellular proteins;
D O I：
10.1016/j.vaccine.2006.02.016
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A mouse model resembling Streptococcus equi subspecies equi infection in the horse, strangles, was used to assess the protective effect of vaccination with selected recombinant proteins from S. equi subsp. equi. After challenge the infection was monitored by weight loss and by nasal colonisation with S. equi subsp. equi. Vaccination with a collagen-binding protein (CNE) and a collagen-like protein (ScIC) resulted in protective antibodies, whereas a novel fibronectin-binding protein (FNEB) did not. Co-administration of CNE with EAG, a poorly immunogenic alpha(2)-macroglobulin-, albumin- and immunoglobulin G-binding protein, resulted in a significant synergistic effect and enhanced the protective immune response against EAG. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4144 / 4151
页数：8
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