Concise Stereoselective Total Synthesis of Leiocarpin C

被引：4

作者：

Rao, Dasireddi Chandra ^{[1
]}

Shekhar, Vanam ^{[1
]}

Reddy, Dorigondla Kumar ^{[1
]}

Chinnababu, Baggu ^{[1
]}

Venkateswarlu, Yenamandra ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Nat Prod Chem, Nat Prod Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

HELVETICA CHIMICA ACTA | 2013年 / 96卷 / 12期

关键词：

Goniothalamus leiocarpus; Leiocarpin C; Lactones; Hydroxylation; K-Selectride; Total synthesis; Stereoselective synthesis; STYRYL-LACTONES; STEREOCHEMISTRY; CYTOTOXICITY;

D O I：

10.1002/hlca.201200656

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and highly concise strategy has been developed for the stereoselective total synthesis of leiocarpin C starting from commercially available mandelic ester. The strategy utilizes the OsO4-catalyzed cis-hydroxylation and selective reduction with K-Selectride as key steps.

引用

页码：2179 / 2184

页数：6

共 24 条

[1]

Blázquez MA, 1999, PHYTOCHEM ANALYSIS, V10, P161, DOI 10.1002/(SICI)1099-1565(199907/08)10:4<161::AID-PCA453>3.0.CO

[2]

2-2

[3] ON STEREOCHEMISTRY OF OSMIUM TETRAOXIDE OXIDATION OF ALLYLIC ALCOHOL SYSTEMS - EMPIRICAL RULE [J].