Short-term memory acquisition in female Huntington's disease mice is vulnerable to acute stress

被引：24
作者：
Mo, Christina [1 ,2 ]
Renoir, Thibault [1 ]
Pang, Terence Y. C. [1 ]
Hannan, Anthony J. [1 ,2 ]
机构：
[1] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3052, Australia
[2] Univ Melbourne, Dept Anat & Neurosci, Parkville, Vic 3052, Australia
来源：
BEHAVIOURAL BRAIN RESEARCH | 2013年 / 253卷
关键词：
Huntington's disease; Short-term memory; Acute stress; Sexual dimorphism; Corticosterone; Y-maze; PITUITARY-ADRENAL AXIS; TRANSGENIC MOUSE MODEL; SEX-DIFFERENCES; SPATIAL MEMORY; RECEPTOR EXPRESSION; WATER MAZE; ONSET; BEHAVIOR; AGE; DEPRESSION;
D O I：
10.1016/j.bbr.2013.07.041
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Huntington's disease (HD) is a neurodegenerative disorder marked by cognitive, psychiatric and motor decline, and is modifiable by unidentified environmental factors. We examined the effects of stress on cognitive function in R6/1 HD transgenic mice. Utilizing the Y-maze to assess short-term memory, we report that only female HD mice displayed vulnerability to 1 h of confinement stress reflected by impaired memory acquisition. This could not be attributed to a different corticosterone response or exploratory behaviour in the task. This is the first demonstration of increased stress susceptibility in an animal model of HD involving a direct negative impact on cognitive function. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：318 / 322
页数：5
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