Antitumoral effects of vasoactive intestinal peptide in human renal cell carcinoma xenografts in athymic nude mice

被引：10
作者：
Vacas, Eva [1 ]
Isabel Arenas, M. [2 ]
Munoz-Moreno, Laura [1 ]
Bajo, Ana M. [1 ]
Sanchez-Chapado, Manuel [3 ,4 ]
Prieto, Juan C. [1 ]
Carmena, Maria J. [1 ]
机构：
[1] Univ Alcala, Dept Syst Biol, Unit Biochem & Mol Biol, Alcala De Henares 28871, Spain
[2] Univ Alcala, Dept Biomed & Biotechnol, Unit Cell Biol & Genet, Alcala De Henares 28871, Spain
[3] Univ Alcala, Dept Surg Med & Social Sci, Surg Unit, Alcala De Henares 28871, Spain
[4] Principe Asturias Hosp, Dept Urol, Alcala De Henares 28871, Spain
来源：
CANCER LETTERS | 2013年 / 336卷 / 01期
关键词：
VIP; MMP; VEGF; NF kappa B; ccRCC; OXIDATIVE STRESS; E-CADHERIN; KAPPA-B; VIP; EXPRESSION; RECEPTORS; CANCER; P53; VHL; MATRIX-METALLOPROTEINASE-9;
D O I：
10.1016/j.canlet.2013.04.033
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We studied antitumor effect of VIP in human renal cell carcinoma (RCC) (A498 cells xenografted in immunosuppressed mice). VIP-treated cells gave resulted in p53 upregulation and decreased nuclear beta-catenin translocation and NP kappa B expression, MMP-2 and MMP-9 activities, VEGF levels and CD-34 expression. VIP led to a more differentiated tubular organization in tumours and less metastatic areas. Thus, VIP inhibits growth of A498-cell tumours acting on the major issues involved in RCC progression such as cell proliferation, microenvironment remodelling, tumour invasion, angiogenesis and metastatic ability. These antitumoral effects of VIP offer new therapeutical possibilities in RCC treatment. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：196 / 203
页数：8
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