Synthesis of Gd(III)-C-palmitamidomethyl-C′-DOTAMA-C6-o-carborane: a new dual agent for innovative MRI/BNCT applications

被引：23

作者：

Aime, Silvio ^{[2
]}

Barge, Alessandro ^{[3
]}

Crivello, Antonella ^{[2
]}

Deagostino, Annamaria ^{[1
]}

Gobetto, Roberto ^{[2
]}

Nervi, Carlo ^{[2
]}

Prandi, Cristina ^{[1
]}

Toppino, Antonio ^{[1
,2
]}

Venturello, Paolo ^{[1
]}

机构：

[1] Univ Turin, Dipartimento Chim Gen & Chim Organ, I-10125 Turin, Italy

[2] Univ Turin, IFM, Dipartimento Chim, I-10125 Turin, Italy

[3] Univ Turin, Dipartimento Sci & Tecnol Farmaco, I-10125 Turin, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2008年 / 6卷 / 23期

关键词：

D O I：

10.1039/b808804g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-(2-Benzyloxy)-ethyl-C'-N-tert-butoxycarbonyl-aminomethyl-o-carborane (8), a potentially useful intermediate for BNCT, has been synthesised. This intermediate can be readily functionalised with several biological vectors and MRI contrast agents. In this work intermediate 8 has been functionalised with a palmityl chain for lipophilic targeting and with Gd(III)-DOTAMA-C-6-NH2 as MRI detector. This combination yielded Gd(III)-C-palmitamidomethyl-C'-DOTAMA-C-6-o-carborane (14) as a dual MRI-BNCT agent.

引用

收藏

页码：4460 / 4466

页数：7

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