Hemolytic uremic syndrome due to an altered factor H triggered by neonatal pertussis

被引：27

作者：

Berner, R

Krause, MF

Gordjani, N

Zipfel, PF

Boehm, N

Krueger, M

Brandis, M

Zimmerhackl, LB

机构：

[1] Univ Freiburg, Childrens Hosp, D-79106 Freiburg, Germany

[2] Hans Knoll Inst Nat Prod Res, D-07745 Jena, Germany

[3] Inst Pathol, D-79110 Freiburg, Germany

来源：

PEDIATRIC NEPHROLOGY | 2002年 / 17卷 / 03期

关键词：

Bordetella pertussis; newborn; hemolytic uremic syndrome; factor H;

D O I：

10.1007/s00467-001-0798-6

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report on a previously healthy newborn suffering from severe Bordetella pertussis infection who developed hemolytic uremic syndrome (HUS) a few weeks after the onset of whooping cough, with a fatal outcome. A factor H protein with abnormal mobility was found in the serum of the patient as analyzed by Western blotting, indicating that B. pertussis infection might have triggered HUS in a genetically predisposed patient.

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页码：190 / 192

页数：3

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