Advances in Studies on Recombinant Adeno-associated Virus Vector

被引:0
作者
Qiu, Yan [1 ]
Yang, Bin [1 ]
Lan, Xi [1 ]
Li, Xue-Ri [1 ]
Yin, Xiang-Ping [1 ]
Liu, Ji-Xing [1 ]
机构
[1] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, State Key Lab Vet Etiol Biol, Key Lab Anim Virol,Minist Agr,Key Lab Epizoot Dis, Lanzhou 730046, Peoples R China
来源
ASIAN JOURNAL OF ANIMAL AND VETERINARY ADVANCES | 2012年 / 7卷 / 12期
关键词
Recombinant Adeno-associated Virus (rAAV); vector; gene therapy; advances; HEPATIC GENE-TRANSFER; AAV VECTORS; FACTOR-IX; VIRAL VECTORS; MOUSE-LIVER; LARGE-SCALE; MICE; EXPRESSION; INTEGRATION; MUSCLE;
D O I
10.3923/ajava.2012.1255.1260
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Recombinant Adeno-associated Virus (rAAV), as a common tool of gene therapy has many merits such as, nonpathogenicity, long-term expression, low immunogenicity, as well as its large-scale infectivity to many kinds of cells. As a result, scientists pay high emphasis on the rAAV. There is no doubt that the rAAV vectors will make great contribution to human health. This study reviewed the progress of the rAAV vector in recent years. It mainly states the characteristics, application, production and security of rAAV.
引用
收藏
页码:1255 / 1260
页数:6
相关论文
共 45 条
  • [1] Azat M., 2011, BIOCHEM BIOPH RES CO, V405, P204
  • [2] Human adeno-associated virus type 5 is only distantly related to other known primate helper-dependent parvoviruses
    Bantel-Schaal, U
    Delius, H
    Schmidt, R
    zur Hausen, H
    [J]. JOURNAL OF VIROLOGY, 1999, 73 (02) : 939 - 947
  • [3] No evidence for tumorigenesis of AAV vectors in a large-scale study in mice
    Bell, P
    Wang, LL
    Lebherz, C
    Flieder, DB
    Bove, MS
    Wu, D
    Gao, GP
    Wilson, JM
    Wivel, NA
    [J]. MOLECULAR THERAPY, 2005, 12 (02) : 299 - 306
  • [4] Inverse zonation of hepatocyte transduction with MV vectors between mice and non-human primates
    Bell, Peter
    Wang, Lili
    Gao, Guangping
    Haskins, Mark E.
    Tarantal, Alice F.
    McCarter, Robert J.
    Zhu, Yanqing
    Yu, Hongwei
    Wilson, James M.
    [J]. MOLECULAR GENETICS AND METABOLISM, 2011, 104 (03) : 395 - 403
  • [5] PARVOVIRUS REPLICATION
    BERNS, KI
    [J]. MICROBIOLOGICAL REVIEWS, 1990, 54 (03) : 316 - 329
  • [6] Buning H., 2008, J GENE MED, V10, P717
  • [7] Carter PJ, 2000, INT J MOL MED, V6, P17
  • [8] Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles
    Chiorini, JA
    Yang, L
    Liu, YJ
    Safer, B
    Kotin, RM
    [J]. JOURNAL OF VIROLOGY, 1997, 71 (09) : 6823 - 6833
  • [9] Cloning and characterization of adeno-associated virus type 5
    Chiorini, JA
    Kim, F
    Yang, L
    Kotin, RM
    [J]. JOURNAL OF VIROLOGY, 1999, 73 (02) : 1309 - 1319
  • [10] Recombinant adeno-associated viral vectors mediate long-term transgene expression in muscle
    Clark, KR
    Sferra, TJ
    Johnson, PR
    [J]. HUMAN GENE THERAPY, 1997, 8 (06) : 659 - 669