The safety of cetirizine during pregnancy. A prospective observational cohort study

被引：56

作者：

Weber-Schoendorfer, Corinna ^{[1
]}

Schaefer, Christof ^{[1
]}

机构：

[1] Pharmakovigilanz & Beratungszentrum Embryonaltoxi, Berlin Inst Clin Teratol & Drug Risk Assessment P, D-14050 Berlin, Germany

来源：

REPRODUCTIVE TOXICOLOGY | 2008年 / 26卷 / 01期

关键词：

pregnancy; cetirizine; antihistamines; human; teratogenicity; fetal outcome; birth defects; cohort study;

D O I：

10.1016/j.reprotox.2008.05.053

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objective: To assess the safety of cetirizine during pregnancy. Study design: A prospective observational cohort study with data of the Berlin teratology information center from 1992 until 2006. Pregnancy outcome was compared between a cohort of pregnant women exposed to cetirizine during the first trimester (n = 196) and a control group not exposed to potential teratogens (n = 1686). Results: Major birth defects were not more common in the study group than in the control group (OR 1.07; CI 0.21-3.59). We also compared the crude rate of spontaneous abortions (OR 0.97: CI 0.54-1.65). of preterm deliveries (OR 0.76; CI 0.35-1.5), and the birth weight of term newborns (p = 0.13). Conclusions: This prospective observational study on cetirizine in pregnancy suggests that the use of cetirizine is relatively safe during the first trimester. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：19 / 23

页数：5

共 8 条

[1] Prospective controlled study of hydroxyzine and cetirizine in pregnancy [J].

Einarson, A ;

Bailey, B ;

Jung, G ;

Spizzirri, D ;

Baillie, M ;

Koren, G .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 1997, 78 (02) :183-186

[2]

Kallen B, 2002, J Matern Fetal Neonatal Med, V11, P146, DOI 10.1080/713605486

[3]

KAMIJIMA M, 1994, CLIN REP, V28, P114

[4] Phenotypic abnormalities: Terminology and classification [J].

Merks, JHM ;

van Karnebeek, CDM ;

Caron, HN ;

Hennekam, RCM .

AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2003, 123A (03) :211-230

[5]

Paulus W, 2004, REPROD TOXICOL, V19, P258

[6] Guidelines for case classification for the national birth defects prevention study [J].

Rasmussen, SA ;

Olney, RS ;

Holmes, LB ;

Lin, AE ;

Keppler-Noreuil, KM ;

Moore, CA .

BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, 2003, 67 (03) :193-201

[7] Vitamin K antagonists and pregnancy outcome - A multi-centre prospective study [J].

Schaefer, Christof ;

Hannemann, Doreen ;

Meister, Reinhard ;

Elefant, Elisabeth ;

Paulus, Wolfgang ;

Vial, Thierry ;

Reuvers, Minke ;

Robert-Gnansia, Elisabeth ;

Arnon, Judy ;

De Santis, Marco ;

Clementi, Maurizio ;

Rodriguez-Pinilla, Elvira ;

Dolivo, Alla ;

Merlob, Paul .

THROMBOSIS AND HAEMOSTASIS, 2006, 95 (06) :949-957

[8]

SWEETMAN SC, 2007, MARTINDALE COMPLETE, P515

← 1 →