Hepatitis C virus infection in Abidjan Cote d Ivoire: heterogeneity of genotypes

被引：0

作者：

Bengue, Alphonsine Kouassi-M ^{[1
]}

Kouacou, Marie Jeanne Lohoues ^{[2
]}

Ekaza, Euloge ^{[1
]}

Siransy-Bogui, Liliane ^{[3
]}

N'Golo, Daniel Coulibaly ^{[1
]}

Labonte, Patrick ^{[4
]}

Dosso, Mireille ^{[1
]}

机构：

[1] CHU Cocody Abidjan, Inst Pasteur Cote Ivoire, Lab Bacteriol Virol, Abidjan, Cote Ivoire

[2] CHU Cocody, Gastro Enterol Dept, Abidjan, Cote Ivoire

[3] Ctr Natl Transfus Sanguine, Abidjan, Cote Ivoire

[4] Univ Quebec, Inst Armand Frappier, INRS, Laval, PQ H7V 1B7, Canada

来源：

SCIENTIFIC RESEARCH AND ESSAYS | 2008年 / 3卷 / 04期

关键词：

HCV; antibodies; RT-PCR; genotypes; Cote d' Ivoire;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Whereas the distribution of HCV genotypes in many countries is well documented, very little is known about the genotypes prevalent in Cote d' Ivoire, in West Africa. This study was undertaken to clarify molecular characteristics of HCV isolated in Cote d' Ivoire. Plasma samples from 2866 blood donors and 100 patients hospitalized at the teaching hospital of Cocody in Medical and Pediatrics' services were collected and screened for HCV antibodies, hepatitis B surface antigen (HBsAg) and HIV antibodies by enzyme immuno assays (EIA). Viral RNA was extracted from anti HCV antibodies positive samples using a one step RT-PCR (Qiagen one-step RT-PCR kit). From blood donors and patients, detection of HCV antibody was positive for 43 (1.5%) and 23 (23%), respectively. Only 27 samples were positive for RNA detection. Concerning genotyping, we observed predominance of genotype 1 (77.8%), followed by genotype 2 (18.5%) and genotype 5 (3.7%). This study revealed heterogeneity of HCV genotypes in Cote d' Ivoire.

引用

页码：139 / 142

页数：4

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