Granulomatous interstitial nephritis:: A clinicopathologic study of 46 cases from a single institution

被引:86
作者
Bijol, V [1 ]
Mendez, GP [1 ]
Nosé, V [1 ]
Rennke, HG [1 ]
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Pathol, Boston, MA 02115 USA
关键词
granulomatous interstitial nephritis; renal granulomas; drug-induced interstitial nephritis; renal sarcoidosis; Wegener's granulomatosis;
D O I
10.1177/106689690601400110
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Acute interstitial nephritis is commonly seen in kidney biopsies of patients with acute renal failure; however, granulomatous interstitial nephritis (GIN) is rare. We identified 46 cases of GIN in a 17-year period in this institution and we investigated their most probable etiologies. Complete clinical information was available in 38 patients. Seventeen of 38 patients (44.7%) were classified as drug-induced. Renal sarcoidosis was responsible for 28.9% of cases, and the remaining 15.9% of cases included Wegeners granulomatosis, foreign body giant cell reaction, GIN secondary to intravesical bacillus Calmette-Guerin therapy for bladder cancer, and xanthogranulomatous pyelonephritis. Clinical investigation failed to reveal possible etiology in 4 patients (10.5%), classified as idiopathic. We concluded that three quarters Of Our cases were either drug-induced or due to sarcoidosis; only a small proportion Of Our cases occurred secondary to any other cause or to unknown factors.
引用
收藏
页码:57 / 63
页数:7
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