Fetal Alcohol Spectrum Disorder and Iron Homeostasis

被引：8

作者：

Bradley, Regan ^{[1
]}

Lakpa, Koffi L. ^{[2
]}

Burd, Michael ^{[1
]}

Mehta, Sunil ^{[3
]}

Katusic, Maja Z. ^{[4
]}

Greenmyer, Jacob R. ^{[4
]}

机构：

[1] Univ North Dakota, Sch Med, Grand Forks, ND 58201 USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI 53706 USA

[3] Mayo Clin, Dev & Behav Pediat Psychiat & Psychol, Rochester, MN 55905 USA

[4] Mayo Clin, Pediat & Adolescent Med, Rochester, MN 55905 USA

来源：

NUTRIENTS | 2022年 / 14卷 / 20期

关键词：

fetal alcohol spectrum disorders; iron deficiency; iron supplementation; maternal; fetal anemia; fetal nutrition; pregnancy; prenatal alcohol exposure; WESTERN CAPE PROVINCE; CELLULAR IRON; REGULATORY PROTEINS; DEFICIENCY ANEMIA; ETHANOL EXPOSURE; DIETARY-INTAKE; RAT MODEL; LONG-TERM; PREGNANCY; BRAIN;

D O I：

10.3390/nu14204223

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Prenatal alcohol exposure results in a spectrum of behavioral, cognitive, and morphological abnormalities collectively referred to as fetal alcohol spectrum disorder (FASD). FASD presents with significant phenotypic variability and may be modified by gestational variables such as maternal nutritional status. Iron serves a critical function in the development of and processes within central nervous system (CNS) structures. Gestational iron deficiency alters CNS development and may contribute to neurodevelopmental impairment in FASD. This review explores the relationship between iron deficiency and fetal alcohol spectrum disorder as described in small animal and human studies. Consideration is given to the pathophysiologic mechanisms linking iron homeostasis and prenatal alcohol exposure. Existing data suggest that iron deficiency contributes to the severity of FASD and provide a mechanistic explanation linking these two conditions.

引用

页数：16

共 90 条

[11] Gestational weight gain and dietary energy, iron, and choline intake predict severity of fetal alcohol growth restriction in a prospective birth cohort [J].