Influence of carboxylic acid functionalities in ruthenium (II) polypyridyl complexes on DNA binding, cytotoxicity and antioxidant activity: Synthesis, structure and in vitro anticancer activity

被引：49
作者：
Kamatchi, Thangavel Sathiya [1 ]
Chitrapriya, Nataraj [2 ]
Kim, Seog K. [2 ]
Fronczek, Frank R. [3 ]
Natarajan, Karuppannan [1 ]
机构：
[1] Bharathiar Univ, Dept Chem, Coimbatore 641046, Tamil Nadu, India
[2] Yeungnam Univ, Dept Chem, Gyeongsan City 712749, Gyeong Buk, South Korea
[3] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 59卷
关键词：
Ruthenium; Bipyridine; Dicarboxylic acid; DNA interaction; Cytotoxicity; Antioxidant activity; TRANSCRIPTION INHIBITION; DEOXYRIBONUCLEIC-ACID; LIGANDS; MODE; INTERCALATION; REDOX; CHEMISTRY; MEDICINE; AFFINITY; DESIGN;
D O I：
10.1016/j.ejmech.2012.11.024
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Four new Ru(II) complexes [RuHCl(bpy)(PPh3)(CO)] (1), [RuHCl(bpy)(AsPh3)(CO)] (2) (bpy = 2,2'-bipyridine), [RuCl(HL)(PPh3)(2)(CO)] (3) and [RuCl(HL)(AsPh3)(2)(CO)] (4) (HL = 2,2'-bipyridine-4,4'-dicarboxylic acid) were synthesized and characterized. X-ray diffraction was used to characterize 3 in solid state. The interactions of these complexes with DNA were explored by different techniques which revealed that the complexes could bind to CT-DNA through non-intercalation. The in vitro cytotoxic and antioxidant activities of the complexes validated against a panel of cancer cell lines and free radicals showed that 3 and 4 possess quite high anticancer and antioxidant activities over 1, 2 and standard drugs. An apparent dependence of biological activities on incorporation of COOH in bipyridine moiety was noticed: Inclusion of COOH caused significant differences in DNA binding, cytotoxicity and antioxidant activity. (C) 2012 Elsevier Masson SAS. All rights reserved.
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收藏
页码：253 / 264
页数：12
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