The viral RNA capping machinery as a target for antiviral drugs

被引：80
作者：
Ferron, Francois
Decroly, Etienne
Selisko, Barbara
Canard, Bruno [1 ]
机构：
[1] CNRS, F-13288 Marseille 09, France
来源：
ANTIVIRAL RESEARCH | 2012年 / 96卷 / 01期
关键词：
5 '-Triphosphatase; Guanylyltransferase; Methyltransferase; Endonuclease; Cap snatching; Mechanism; Structure; Inhibitor; VIRUS MESSENGER-RNA; RESPIRATORY SYNCYTIAL VIRUS; VESICULAR STOMATITIS-VIRUS; NONSTRUCTURAL PROTEIN NSP1; DENGUE VIRUS; IN-VITRO; INFLUENZA-VIRUS; MOSAIC-VIRUS; FLAVIVIRUS METHYLTRANSFERASE; PREDOMINANT MECHANISM;
D O I：
10.1016/j.antiviral.2012.07.007
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Most viruses modify their genomic and mRNA 5'-ends with the addition of an RNA cap, allowing efficient mRNA translation, limiting degradation by cellular 5'-3' exonucleases, and avoiding its recognition as foreign RNA by the host cell. Viral RNA caps can be synthesized or acquired through the use of a capping machinery which exhibits a significant diversity in organization, structure and mechanism relative to that of their cellular host. Therefore, viral RNA capping has emerged as an interesting field for antiviral drug design. Here, we review the different pathways and mechanisms used to produce viral mRNA 5'-caps, and present current structures, mechanisms, and inhibitors known to act on viral RNA capping. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：21 / 31
页数：11
相关论文
共 102 条
[1]   5' TERMINAL STRUCTURE OF METHYLATED MESSENGER-RNA SYNTHESIZED INVITRO BY VESICULAR STOMATITIS-VIRUS [J].
ABRAHAM, G ;
RHODES, DP ;
BANERJEE, AK .
CELL, 1975, 5 (01) :51-58
[2]   NOVEL INITIATION OF RNA-SYNTHESIS INVITRO BY VESICULAR STOMATITIS-VIRUS [J].
ABRAHAM, G ;
RHODES, DP ;
BANERJEE, AK .
NATURE, 1975, 255 (5503) :37-40
[3]   Critical residues of Semliki Forest virus RNA capping enzyme involved in methyltransferase and guanylyltransferase-like activities [J].
Ahola, T ;
Laakkonen, P ;
Vihinen, H ;
Kaariainen, L .
JOURNAL OF VIROLOGY, 1997, 71 (01) :392-397
[4]   Putative RNA capping activities encoded by brome mosaic virus: Methylation and covalent binding of guanylate by replicase protein 1a [J].
Ahola, T ;
Ahlquist, P .
JOURNAL OF VIROLOGY, 1999, 73 (12) :10061-10069
[5]   REACTION IN ALPHAVIRUS MESSENGER-RNA CAPPING - FORMATION OF A COVALENT COMPLEX OF NONSTRUCTURAL PROTEIN NSP1 WITH 7-METHYL-GMP [J].
AHOLA, T ;
KAARIAINEN, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (02) :507-511
[6]   Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis [J].
Almazan, Fernando ;
DeDiego, Marta L. ;
Galan, Carmen ;
Escors, David ;
Alvarez, Enrique ;
Ortego, Javier ;
Sola, Isabel ;
Zuniga, Sonia ;
Alonso, Sara ;
Moreno, Jose L. ;
Nogales, Aitor ;
Capiscol, Carmen ;
Enjuanes, Luis .
JOURNAL OF VIROLOGY, 2006, 80 (21) :10900-10906
[7]   THE STRUCTURE OF THE 5' TERMINAL CAP OF THE RESPIRATORY SYNCYTIAL VIRUS MESSENGER-RNA [J].
BARIK, S .
JOURNAL OF GENERAL VIROLOGY, 1993, 74 :485-490
[8]   The RNA helicase, nucleotide 5′-triphosphatase, and RNA 5′-triphosphatase activities of Dengue virus protein NS3 are Mg2+-dependent and require a functional Walker B motif in the helicase catalytic core [J].
Benarroch, D ;
Selisko, B ;
Locatelli, GA ;
Maga, G ;
Romette, JL ;
Canard, B .
VIROLOGY, 2004, 328 (02) :208-218
[9]   A structural basis for the inhibition of the NS5 dengue virus mRNA 2′-O-Methyltransferase domain by ribavirin 5′-triphosphate [J].
Benarroch, D ;
Egloff, MP ;
Mulard, L ;
Guerreiro, C ;
Romette, JL ;
Canard, B .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (34) :35638-35643
[10]   Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain [J].
Benarroch, Delphine ;
Smith, Paul ;
Shuman, Stewart .
STRUCTURE, 2008, 16 (04) :501-512
12345678910