Experimental models of traumatic brain injury: Do we really need to build a better mousetrap?

被引:251
作者
Morales, DM
Marklund, N
Lebold, D
Thompson, HJ
Pitkanen, A
Maxwell, WL
Longhi, L
Laurer, H
Maegele, M
Neugebauer, E
Graham, DI
Stocchetti, N
McIntosh, TK
机构
[1] Univ Penn, Traumat Brain Injury Lab, Dept Neurosurg, Philadelphia, PA 19104 USA
[2] Vet Adm Med Ctr, Philadelphia, PA 19104 USA
[3] Univ Uppsala Hosp, Dept Neurosurg, Uppsala, Sweden
[4] Univ Washington, Dept Biobehav Nursing & Hlth Syst, Seattle, WA 98195 USA
[5] Univ Kuopio, Epilepsy Res Lab, AI Virtanen Inst Mol Sci, FIN-70211 Kuopio, Finland
[6] Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland
[7] Univ Glasgow, Inst Biomed & Life Sci, Glasgow, Lanark, Scotland
[8] Osped Maggiore Policlin IRCCS, Neurosurg Intens Care Unit, Dept Anesthesia & Crit Care Med, Milan, Italy
[9] Goethe Univ Frankfurt, Dept Trauma Surg, D-6000 Frankfurt, Germany
[10] Univ Cologne, Biochem & Expt Div, Cologne, Germany
[11] So Gen Hosp, Dept Neuropathol, Inst Neurol Sci, Glasgow, Lanark, Scotland
关键词
review; diffuse injury; focal injury; head injury; literature review;
D O I
10.1016/j.neuroscience.2005.08.030
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Approximately 4000 human beings experience a traumatic brain injury each day in the United States ranging in severity from mild to fatal. Improvements in initial management, surgical treatment, and neurointensive care have resulted in a better prognosis for traumatic brain injury patients but, to date, there is no available pharmaceutical treatment with proven efficacy, and prevention is the major protective strategy. Many patients are left with disabling changes in cognition, motor function, and personality. Over the past two decades, a number of experimental laboratories have attempted to develop novel and innovative ways to replicate, in animal models, the different aspects of this heterogenous clinical paradigm to better understand and treat patients after traumatic brain injury. Although several clinically-relevant but different experimental models have been developed to reproduce specific characteristics of human traumatic brain injury, its heterogeneity does not allow one single model to reproduce the entire spectrum of events that may occur. The use of these models has resulted in an increased understanding of the pathophysiology of traumatic brain injury, including changes in molecular and cellular pathways and neurobehavioral outcomes. This review provides an up-to-date and critical analysis of the existing models of traumatic brain injury with a view toward guiding and improving future research endeavors. (c) 2005 Published by Elsevier Ltd on behalf of IBRO.
引用
收藏
页码:971 / 989
页数:19
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