Formaldehyde toxicity reports fromin vitroandin vivostudies: a review and updated data

被引：78
作者：
Bernardini, Leticia [1 ]
Barbosa, Eduardo [2 ]
Charao, Mariele Feiffer [2 ]
Brucker, Natalia [1 ,3 ]
机构：
[1] Univ Fed Santa Maria, Grad Program Pharmacol, Santa Maria, RS, Brazil
[2] Univ Feevale, Grad Program Toxicol & Analyt Toxicol, Novo Hamburgo, Brazil
[3] Univ Fed Santa Maria, Dept Physiol & Pharmacol, Av Roraima 1000, BR-97105900 Santa Maria, RS, Brazil
来源：
DRUG AND CHEMICAL TOXICOLOGY | 2022年 / 45卷 / 03期
关键词：
Formaldehyde exposure; toxicity; cytotoxicity; inflammation; oxidative stress; PROTEIN CROSS-LINKS; BONE-MARROW-CELLS; OCCUPATIONAL-EXPOSURE; DOSE FORMALDEHYDE; NASOPHARYNGEAL CANCER; CHROMOSOME CHANGES; MYELOID-LEUKEMIA; OXIDATIVE STRESS; IN-VITRO; WORKERS;
D O I：
10.1080/01480545.2020.1795190
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Formaldehyde (FA) is a xenobiotic air pollutant and its universal distribution causes a widespread exposure to humans. This review aimed to bring updated information concerning FA toxicity in humans and animals based onin vitroandin vivostudies from 2013 to 2019. Researches were carried out in Pubmed, Scopus, and Science Direct databases to determine the effects of FA exposure on inflammation, oxidative stress and genotoxicity in experimental studies with animals (rats and mice) and humans. Besides,in vitrostudies assessing FA cytotoxicity focusing on cell viability and apoptosis in different cell line cultures were reviewed. Studies with humans gave evidence regarding significant deleterious effects on health associated to chronic FA occupational exposure. Evaluations carried out in experimental studies showed toxic effects on different organs as lung, upper respiratory tract, bone marrow and brain as well as in cells. In summary, this study demonstrates that knowing the mechanisms underlying FA toxicity is essential to understand the deleterious effects that this xenobiotic causes on biological systems.
引用
收藏
页码：972 / 984
页数：13
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