Carbamate linkers as latent N-methylamines in solid phase synthesis

被引：39

作者：

Ho, CY

Kukla, MJ

机构：

[1] Chemistry Department, Janssen Research Foundation, Spring House

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(97)00510-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new linker strategy for solid phase synthesis has been developed. It utilizes LAH reduction of a carbamate connection to Wang resin which results in N-methylamines, a useful functionality in medicinal chemistry. (C) 1997 Elsevier Science Ltd.

引用

页码：2799 / 2802

页数：4

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