3-Hydroxy-3-methylglutaryl flavone glycosides from the leaves of Turpinia arguta

被引：9

作者：

Ma, Shuang-Gang

Yuan, Shao-Peng

Liu, Yun-Bao

Qu, Jing

Li, Yong

Wang, Xiao-Jing

Wang, Ru-Bing

Xu, Song

Hou, Qi

Yu, Shi-Shan ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

来源：

FITOTERAPIA | 2018年 / 124卷

关键词：

Turpinia arguta; Flavone glycosides; HMG; Argutosides; NO inhibition; ABSOLUTE-CONFIGURATION; CITRUS-SUDACHI; CONSTITUENTS;

D O I：

10.1016/j.fitote.2017.10.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new 3-hydroxy-3-methylglutaryl (HMG) flavone 7-O-diglycosides, argutosides A-C (1-3); two new flavone 7-O-triglycosides, argutosides D-E (4-5); and one known apigenin 7-O-triglycoside (6), were isolated from the leaves of Trapinia arguta. The structures of these compounds were elucidated by spectroscopic and chemical techniques. The NO inhibitory activities of compounds 1-6 were evaluated using lipopolysaccharide-induced RAW264.7 cells. Only compound 2 showed a moderate inhibitory effect on NO production with an IC50 value of 25.74 mu M. Compounds 1-6 were not cytotoxic to RAW264.7 cells at 10 mu M.

引用

页码：80 / 85

页数：6

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