Current and Future Anatomical and Functional Imaging Approaches to Pheochromocytoma and Paraganglioma

被引：51

作者：

Timmers, H. J. L. M. ^{[2
]}

Taieb, D. ^{[3
]}

Pacak, K. ^{[1
]}

机构：

[1] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA

[2] Radboud Univ Nijmegen, Med Ctr, Dept Endocrinol, NL-6525 ED Nijmegen, Netherlands

[3] Aix Marseille Univ, La Timone Univ Hosp, Dept Nucl Med, Marseille, France

来源：

HORMONE AND METABOLIC RESEARCH | 2012年 / 44卷 / 05期

关键词：

FDG PET; MIBG scintigraphy; FDOPA PET; FDA PET; POSITRON-EMISSION-TOMOGRAPHY; IN-111-PENTETREOTIDE SCINTIGRAPHY; NECK PARAGANGLIOMAS; I-123; METAIODOBENZYLGUANIDINE; METASTATIC PHEOCHROMOCYTOMA; OCTREOTIDE SCINTIGRAPHY; MIBG SCINTIGRAPHY; PET; HEAD; LOCALIZATION;

D O I：

10.1055/s-0031-1299712

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

After establishing a biochemical diagnosis, pheochromocytomas and extra-adrenal paragangliomas (PPGLs) can be localized using different anatomical and functional imaging modalities. These include computed tomography, magnetic resonance imaging, single-photon emission computed tomography (SPECT) using I-123-metaiodobenzylguanidine or In-111-DTPA-pentetreotide, and positron emission tomography (PET) using 6-[F-18]-fluorodopamine (F-18-FDA), 6-[F-18]-fluoro-L-3,4-dihydroxyphenylalanine (F-18-DOPA), and 2-[F-18]-fluoro-2-deoxy-D-glucose. We review the currently available data on the performance of anatomical imaging, SPECT, and PET for the detection of (metastatic) PPGL as well as parasympathetic head and neck paragangliomas. We show that there appears to be no 'gold-standard' imaging technique for all patients with (suspected) PPGL. A tailor-made approach is warranted, guided by clinical, biochemical, and genetic characteristics. In the current era of a growing number of PET tracers, PPGL imaging has moved beyond tumor localization towards functional characterization of tumors.

引用

页码：367 / 372

页数：6

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