Sphingosine-1-Phosphate and Lymphocyte Egress from Lymphoid Organs

被引:655
作者
Cyster, Jason G. [1 ,2 ]
Schwab, Susan R. [3 ,4 ]
机构
[1] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[3] NYU, Sch Med, Skirball Inst Biomol Med, Program Mol Pathogenesis, New York, NY 10016 USA
[4] NYU, Sch Med, Skirball Inst Biomol Med, Dept Pathol, New York, NY 10016 USA
来源
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 | 2012年 / 30卷
关键词
cell migration; S1P; CD69; lymph node; thymus; FTY720; SPHINGOSINE 1-PHOSPHATE RECEPTOR; IMMATURE B-CELLS; NAIVE T-CELLS; MARGINAL ZONE; ENDOTHELIAL-CELLS; DENDRITIC CELLS; L-SELECTIN; SURFACE EXPRESSION; DISTINCT FUNCTIONS; THYMIC EMIGRATION;
D O I
10.1146/annurev-immunol-020711-075011
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Much has been learned about how cells enter lymphoid tissues. But how do they leave? Sphingosine-1-phosphate (S1P) has emerged over the past decade as a central mediator of lymphocyte egress. In this review, we summarize the current understanding of how S1P promotes exit from the secondary lymphoid organs and thymus. We review what is known about additional requirements for emigration and summarize the mostly distinct requirements for exit from the bone marrow. Egress from lymphoid organs is limited during immune responses, and we examine how this regulation works. There is accumulating evidence for roles of S1P in directing immune cell behavior within lymphoid tissues. How such actions can fit together with the egress-promoting role of S1P is discussed. Finally, we examine current understanding of how FTY720, a drug that targets S1P receptors and is approved for the treatment of multiple sclerosis, causes immune suppression.
引用
收藏
页码:69 / 94
页数:26
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