Autoimmune hepatitis: East meets west

被引：39

作者：

Yang, Fan ^{[1
]}

Wang, Qixia ^{[1
]}

Bian, Zhaolian ^{[1
]}

Ren, Lin-Lin ^{[1
]}

Jia, Jidong ^{[2
,3
]}

Ma, Xiong ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Renji Hosp,Sch Med,Shanghai Canc Inst, Key Lab Gastroenterol & Hepatol,Minist Hlth,Div G, Shanghai 200001, Peoples R China

[2] Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China

[3] Capital Med Univ, Beijing Friendship Hosp, Clin Epidemiol & EBM Unit, Beijing 100050, Peoples R China

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2015年 / 30卷 / 08期

基金：

中国国家自然科学基金;

关键词：

autoimmune disease; autoimmune hepatitis; autoimmune liver disease; liver disease; PRIMARY BILIARY-CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; LIVER-TRANSPLANTATION; HEPATOCELLULAR-CARCINOMA; CLINICAL-FEATURES; DIAGNOSTIC-CRITERIA; CONTROLLED-TRIAL; RISK-FACTORS; FOLLOW-UP; POPULATION;

D O I：

10.1111/jgh.12952

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Autoimmune hepatitis (AIH) is an inflammatory liver disease with diverse clinical spectrum, which predominantly affects females. This review provides detailed comparisons of epidemiology, genetic predispositions, clinical features, risk factors of hepatocellular carcinoma, and mortality in AIH patients between eastern and western countries. AIH prevalence and incidence are lower in Asia-Pacific area than in Europe and America. European and American patients seem to have more severe disease, characterized with human leukocyte antigen-DR3 haplotype, younger age, more AIH-induced cirrhosis at diagnosis, higher elevated serum immunoglobulin G levels, and positive rate of antisoluble liver antigen/liver pancreatitis. The overall AIH diagnostic accuracy of revised original criteria and simplified scoring system are similar in European/American populations and Asian. Cirrhosis at presentation and non-response to immunosuppressive therapy within 1 year are the most important predictors for poor prognosis of AIH patients.

引用

页码：1230 / 1236

页数：7

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