Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure

被引：55

作者：

Obrig, Tom G. ^{[1
]}

Karpman, Diana ^{[2
]}

机构：

[1] Univ Maryland, Dept Microbiol & Immunol, Sch Med, Baltimore, MD 21201 USA

[2] Lund Univ, Dept Pediat, Clin Sci Lund, Lund, Sweden

来源：

RICIN AND SHIGA TOXINS: PATHOGENESIS, IMMUNITY, VACCINES AND THERAPEUTICS | 2012年 / 357卷

关键词：

HEMOLYTIC-UREMIC SYNDROME; MICROVASCULAR ENDOTHELIAL-CELLS; ENTEROHEMORRHAGIC ESCHERICHIA-COLI; TUBULAR EPITHELIAL-CELLS; TUMOR-NECROSIS-FACTOR; TOLL-LIKE RECEPTORS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; HUMAN MONOCLONAL-ANTIBODY; VON-WILLEBRAND-FACTOR; TISSUE-FACTOR;

D O I：

10.1007/82_2011_172

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The kidneys are the major organs affected in diarrhea-associated hemolytic uremic syndrome (D+HUS). The pathophysiology of renal disease in D+HUS is largely the result of the interaction between bacterial virulence factors such as Shiga toxin and lipopolysaccharide and host cells in the kidney and in the blood circulation. This chapter describes in detail the current knowledge of how these bacterial toxins may lead to kidney disease and renal failure. The toxin receptors expressed by specific blood and resident renal cell types are also discussed as are the actions of the toxins on these cells.

引用

页码：105 / 136

页数：32

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