Post-recurrence survival in completely resected stage I non-small cell lung cancer with local recurrence

被引:131
作者
Hung, J-J [1 ,2 ,3 ,4 ,5 ]
Hsu, W-H [1 ,2 ]
Hsieh, C-C [1 ,2 ]
Huang, B-S [1 ,2 ]
Huang, M-H [1 ,2 ]
Liu, J-S [4 ,5 ]
Wu, Y-C [1 ,2 ]
机构
[1] Taipei Vet Gen Hosp, Dept Surg, Div Thorac Surg, Taipei Vet Gen Hosp, Taipei 112, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
[3] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan
[4] Fu Jen Catholic Univ, Dept Surg, Cathay Gen Hosp, Taipei, Taiwan
[5] Fu Jen Catholic Univ, Sch Med, Taipei, Taiwan
关键词
FORTHCOMING 7TH EDITION; BREAST-CANCER; TNM CLASSIFICATION; PREMENOPAUSAL WOMEN; MALIGNANT-TUMORS; RADIOTHERAPY; CHEMOTHERAPY; PROPOSALS; REVISION; PROJECT;
D O I
10.1136/thx.2007.094912
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Objective: Resection is the best treatment for patients with stage I non-small cell lung cancer (NSCLC). Patterns of disease recurrence after complete resection in stage I NSCLC have not been well demonstrated. The aim of this study was to evaluate the prognostic predictors of post-recurrence survival in patients with resected stage I NSCLC with local recurrence. Methods: The clinicopathological characteristics of 123 patients with local recurrence after complete resection of stage I NSCLC in Taipei Veterans General Hospital between 1980 and 2000 were retrospectively reviewed. Post-recurrence survival and their predictors were analysed. Results: The patterns of local recurrence included local only in 74 (60.2%) and both local and distant in 49 (39.8%) patients. The 1 and 2 year post-recurrence survival rates for the 74 patients with local only recurrence were 48.7% and 17.6%, respectively. Tumour size (p= 0.033) and treatment for initial recurrence (p < 0.001) were significant predictors for post-recurrence survival in 74 patients with local only recurrence in univariate analyses. The hazard of death was greater in patients with larger tumour size. Treatment for initial recurrence (p= 0.001) was still a significant prognostic indicator in multivariate analyses. Patients who underwent reoperation after local recurrence survived longer than those who received chemotherapy and/or radiotherapy and those that received no treatment. Conclusions: Treatment for initial recurrence is a prognostic predictor for post-recurrence survival in resected stage I NSCLC with local recurrence. Complete surgical resection should be considered in selected candidates with resectable local recurrent disease.
引用
收藏
页码:192 / 196
页数:5
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