Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.

被引：0
作者：
She, Q.-B.
Chandarlapaty, S.
Ye, Q.
Lobo, J.
Haskell, K. M.
Leander, K. R.
DeFeo-Jones, D.
Huber, H. E.
Rosen, N.
机构：
[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
[2] Merck Res Labs, West Point, PA USA
来源：
CANCER RESEARCH | 2009年 / 69卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：222S / 222S
页数：1
相关论文
共 50 条
[31]   HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway:: An unexpected effect on TRAIL-induced apoptosis [J].
Dubská, L ;
Andera, L ;
Sheard, MA .
FEBS LETTERS, 2005, 579 (19) :4149-4158
[32]   Calorie restriction reduces PI3K/Akt signaling and tumorigenic potential in HER2-overexpressing breast cancer [J].
Smith, Laura A. ;
Rainey, Magdalena A. ;
Sheth, Nishita T. ;
O'Flanagan, Ciara H. ;
Bowers, Laura W. ;
Hursting, Stephen D. .
CANCER RESEARCH, 2018, 78 (13)
[33]   Compartmentalized PI3K/Akt/mTOR Signaling in Living Cells [J].
Zhang, Jin .
FASEB JOURNAL, 2015, 29
[34]   More antitumor efficacy of the PI3K inhibitor GDC-0941 in breast cancer with PIK3CA mutation or HER2 amplification status in vitro [J].
Zheng, Jie ;
Wang, Huan ;
Yao, Jia ;
Zou, Xianjin .
PHARMAZIE, 2014, 69 (01) :38-42
[35]   Targeting HER2 and PI3K in Uterine Serous Cancer [J].
Diver, E. J. ;
Hernandez, S. F. ;
Scaltriti, M. ;
Rueda, B. R. ;
Growdon, W. B. .
GYNECOLOGIC ONCOLOGY, 2015, 139 (03) :596-596
[36]   Targeting the PI3K/Akt/mTOR pathway in estrogen-receptor positive HER2 negative advanced breast cancer [J].
du Rusquec, Pauline ;
Blonz, Cyriac ;
Frenel, Jean Sebastien ;
Campone, Mario .
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2020, 12
[37]   Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer [J].
Li, Huayi ;
Prever, Lorenzo ;
Hirsch, Emilio ;
Gulluni, Federico .
CANCERS, 2021, 13 (14)
[38]   PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis [J].
Fang, Jing ;
Ding, Min ;
Yang, Lily ;
Liu, Ling-Zhi ;
Jiang, Bing-Hua .
CELLULAR SIGNALLING, 2007, 19 (12) :2487-2497
[39]   hMENA11a contributes to HER3-mediated resistance to PI3K inhibitors in HER2 overexpressing breast cancer cells [J].
Trono, Paola ;
Di Modugno, Francesca ;
Circo, Rita ;
Spada, Sheila ;
Melchionna, Roberta ;
Palermo, Belinda ;
Panetta, Mariangela ;
Matteoni, Silvia ;
Soddu, Silvia ;
De Maria, Ruggero ;
Nistico, Paola .
CANCER RESEARCH, 2015, 75
[40]   The interplay of HER2/HER3/PI3K and EGFR/HER2/PLC-γ1 signalling in breast cancer cell migration and dissemination [J].
Balz, Lydia M. ;
Bartkowiak, Kai ;
Andreas, Antje ;
Pantel, Klaus ;
Niggemann, Bernd ;
Zaenker, Kurt S. ;
Brandt, Burkhard H. ;
Dittmar, Thomas .
JOURNAL OF PATHOLOGY, 2012, 227 (02) :234-244
12345