Strategies to augment volitional and reflex function may improve locomotor capacity following incomplete spinal cord injury

被引:5
作者
Leech, Kristan A. [1 ]
Kim, Hyosub E. [2 ]
Hornby, T. George
机构
[1] Johns Hopkins Univ, Dept Neurosci, Baltimore, MD USA
[2] Univ Calif Berkeley, Dept Psychol, 3210 Tolman Hall, Berkeley, CA 94720 USA
关键词
exercise; locomotion; rehabilitation; VOLUNTARY ACTIVATION LEVEL; PLATEAU-LIKE BEHAVIOR; NEUROTROPHIC FACTOR; TRAINING INTENSITY; H-REFLEX; SEROTONERGIC MEDICATIONS; PRESYNAPTIC INHIBITION; CONSTITUTIVE ACTIVITY; RECEPTOR ACTIVATION; SPASTIC HYPERTONIA;
D O I
10.1152/jn.00051.2017
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Many studies highlight the remarkable plasticity demonstrated by spinal circuits following an incomplete spinal cord injury (SCI). Such plasticity can contribute to improvements in volitional motor recovery, such as walking function, although similar mechanisms underlying this recovery may also contribute to the manifestation of exaggerated responses to afferent input, or spastic behaviors. Rehabilitation interventions directed toward augmenting spinal excitability have shown some initial success in improving locomotor function. However, the potential effects of these strategies on involuntary motor behaviors may be of concern. In this article, we provide a brief review of the mechanisms underlying recovery of volitional function and exaggerated reflexes, and the potential overlap between these changes. We then highlight findings from studies that explore changes in spinal excitability during volitional movement in controlled conditions, as well as altered kinematic and behavioral performance during functional tasks. The initial focus will be directed toward recovery of reflex and volitional behaviors following incomplete SCI, followed by recent work elucidating neurophysiological mechanisms underlying patterns of static and dynamic muscle activation following chronic incomplete SCI during primarily single-joint movements. We will then transition to studies of locomotor function and the role of altered spinal integration following incomplete SCI, including enhanced excitability of specific spinal circuits with physical and pharmacological interventions that can modulate locomotor output. The effects of previous and newly developed strategies will need to focus on changes in both volitional function and involuntary spastic reflexes for the successful translation of effective therapies to the clinical setting.
引用
收藏
页码:894 / 903
页数:10
相关论文
共 123 条
[81]   BDNF and activity-dependent synaptic modulation [J].
Lu, B .
LEARNING & MEMORY, 2003, 10 (02) :86-98
[82]   Treadmill Exercise Activates Subcortical Neural Networks and Improves Walking After Stroke A Randomized Controlled Trial [J].
Luft, Andreas R. ;
Macko, Richard F. ;
Forrester, Larry W. ;
Villagra, Federico ;
Ivey, Fred ;
Sorkin, John D. ;
Whitall, Jill ;
McCombe-Waller, Sandy ;
Katzel, Leslie ;
Goldberg, Andrew P. ;
Hanley, Daniel F. .
STROKE, 2008, 39 (12) :3341-3350
[83]  
Lundberg A., 1975, The nervous system, V1, P253
[84]   Recruitment of spinal motor pools during voluntary movements versus stepping after human spinal cord injury [J].
Maegele, M ;
Müller, S ;
Wernig, A ;
Edgerton, VR ;
Harkema, SJ .
JOURNAL OF NEUROTRAUMA, 2002, 19 (10) :1217-1229
[85]   Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors [J].
Murray, Katherine C. ;
Nakae, Aya ;
Stephens, Marilee J. ;
Rank, Michelle ;
D'Amico, Jessica ;
Harvey, Philip J. ;
Li, Xiaole ;
Harris, R. Luke W. ;
Ballou, Edward W. ;
Anelli, Roberta ;
Heckman, Charles J. ;
Mashimo, Takashi ;
Vavrek, Romana ;
Sanelli, Leo ;
Gorassini, Monica A. ;
Bennett, David J. ;
Fouad, Karim .
NATURE MEDICINE, 2010, 16 (06) :694-U99
[86]   Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain [J].
Neeper, SA ;
GomezPinilla, F ;
Choi, J ;
Cotman, CW .
BRAIN RESEARCH, 1996, 726 (1-2) :49-56
[87]  
NIELSEN J, 1993, EXP BRAIN RES, V97, P173
[88]   Effects of drugs on walking after spinal cord injury [J].
Norman, KE ;
Pepin, A ;
Barbeau, H .
SPINAL CORD, 1998, 36 (10) :699-715
[89]   Tension regulation during lengthening and shortening actions of the human soleus muscle [J].
Pinniger, GJ ;
Steele, JR ;
Thorstensson, A ;
Cresswell, AG .
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, 2000, 81 (05) :375-383
[90]   Speed-dependent treadmill training in ambulatory hemiparetic stroke patients -: A randomized controlled trial [J].
Pohl, M ;
Mehrholz, J ;
Ritschel, C ;
Rückriem, S .
STROKE, 2002, 33 (02) :553-558