G-protein-coupled receptor heterodimers: pharmacology, function and relevance to drug discovery

被引：108
作者：
Milligan, Graeme [1 ]
机构：
[1] Univ Glasgow, Mol Pharmacol Grp, Div Biochem & Mol Biol, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
来源：
DRUG DISCOVERY TODAY | 2006年 / 11卷 / 11-12期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
D O I：
10.1016/j.drudis.2006.04.007
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The growing recognition that members of the rhodopsin-like family A G-protein-coupled receptors (GPCRs) exist and function as dimers or higher-order oligomers, and that GPCR hetero-dimers and oligomers are present in physiological tissues, offers novel opportunities for drug discovery. Differential pharmacology, function and regulation of GPCR hetero-dimers and -oligomers suggest means to selectively target GPCRs in different tissues and hint that the mechanism of function of several pharmacological agents might be different in vivo than anticipated from simple ligand-screening programmes that rely on heterologous expression of a single GPCR.
引用
收藏
页码：541 / 549
页数：9
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