Thrombolysis in dementia patients with acute stroke: is it justified?

被引：16

作者：

Paciaroni, Maurizio ^{[1
,2
]}

Pantoni, Leonardo ^{[3
]}

机构：

[1] Univ Perugia, Santa Maria della Misericordia Hosp, Stroke Unit, I-06126 Perugia, Italy

[2] Univ Perugia, Santa Maria della Misericordia Hosp, Div Cardiovasc Med, I-06126 Perugia, Italy

[3] Univ Florence, Neurosci Sect, NEUROFARBA Dept, Florence, Italy

来源：

NEUROLOGICAL SCIENCES | 2017年 / 38卷 / 01期

关键词：

rt-PA; Cerebral hemorrhage; Small vessel disease; Dementia; Amyloid angiopathy; Outcome; ACUTE ISCHEMIC-STROKE; INTRACEREBRAL HEMORRHAGE; INTRAVENOUS THROMBOLYSIS; CEREBRAL MICROBLEEDS; LEUKOARAIOSIS; RISK; METAANALYSIS; OUTCOMES; CARE;

D O I：

10.1007/s10072-016-2725-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The administration of thrombolytic therapy in elderly patients with dementia and acute ischemic stroke may be controversial, because the reported risk of rt-PA associated intracerebral hemorrhage in these patients is higher compared with that of patients without dementia and because these patients are already disabled. Moreover, there are known risk factors for hemorrhagic transformation in patients with dementia: amyloid angiopathy, leukoaraiosis and the presence of microbleeds. In this review, we describe the impact of dementia on functional outcome following thrombolytic therapy for acute ischemic stroke and discuss some of the issues related to the use of this therapy in this specific patient's population.

引用

页码：27 / 31

页数：5

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