Regulation of Polycomb Repression by O-GlcNAcylation: Linking Nutrition to Epigenetic Reprogramming in Embryonic Development and Cancer

被引：16
作者：
Decourcelle, Amelie [1 ]
Leprince, Dominique [1 ]
Dehennaut, Vanessa [1 ]
机构：
[1] Univ Lille, Inst Pasteur Lille, CNRS, UMR8161,M3T Mech Tumorigenesis & Targeted Therapi, Lille, France
来源：
FRONTIERS IN ENDOCRINOLOGY | 2019年 / 10卷
关键词：
O-GlcNAcylation; Polycomb; epigenetic; drosophila development; cancer; PROTEIN STABILITY; DROSOPHILA; EZH2; GENE; COMPLEX; EXPRESSION; GLUCOSE; PROLIFERATION; MIGRATION; GLCNACASE;
D O I：
10.3389/fendo.2019.00117
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Epigenetic modifications are major actors of early embryogenesis and carcinogenesis and are sensitive to nutritional environment. In recent years, the nutritional sensor O-GlcNAcylation has been recognized as a key regulator of chromatin remodeling. In this review, we summarize and discuss recent clues that OGT and O-GlcNAcylation intimately regulate the functions of the Polycomb group proteins at different levels especially during Drosophila melanogaster embryonic development and in human cancer cell lines. These observations define an additional connection between nutrition and epigenetic reprogramming associated to embryonic development and cancer.
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页数：9
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