Identification of the novel HLA-B*13:02:13 allele in a Taiwanese haematopoietic stem cell donor and the probable HLA haplotype in association with B*13:02:13

被引：1
作者：
Yang, K. L. [1 ,2 ,3 ,4 ]
Lee, S. K. [1 ,2 ,3 ]
Lin, P. Y. [1 ,2 ,3 ]
机构：
[1] Buddhist Compass Relief Tzu Chi Fdn, Immunogenet Lab, Hualien 970, Taiwan
[2] Buddhist Compass Relief Tzu Chi Fdn, Buddhist Tzu Chi Stem Cells Ctr, Cord Blood Bank, Hualien 970, Taiwan
[3] Buddhist Compass Relief Tzu Chi Fdn, Buddhist Tzu Chi Gen Hosp, Marrow Donor Registry, Hualien 970, Taiwan
[4] Buddhist Tzu Chi Univ, Buddhist Compass Relief Tzu Chi Fdn, Dept Med Biotechnol, Hualien, Taiwan
来源：
INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2013年 / 40卷 / 03期
关键词：
LEUKOCYTE ANTIGEN-A;
D O I：
10.1111/j.1744-313X.2012.01154.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Using sequence-based typing method, we found a new HLA-B*13:02 variant, B*13:02:13, in a Taiwanese haematopoietic stem cell donor. The DNA sequence of B*13:02:13 is identical to the sequence of B*13:02:01 in exons 2 and 3 except the nucleotide at position 588 where G is replaced by T (codon 172; CTGCTT). The DNA sequence variation did not alter the amino acid sequence of B*13:02:01. The generation of B*13:02:13 is thought to derive from B*13:02:01 as a result of a silence mutation. The probable HLA-A, HLA-B and HLA-DRB1 haplotype in association with B*13:02:1 may be deduced as HLA-A*24-B*13:02:13-DRB1*07:01 or HLA-A*02-B*13:02:13-DRB1*07:01. The discovery of B*13:02:13 furthers the polymorphism of HLA-B*13 and HLA-B*13:02.
引用
收藏
页码：241 / 242
页数：2
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