Aims: To analyze the results obtained after doing saturation prostate biopsy to a series of patients with high level of PSA. Subjects, material and method: Among 2006 and 2007 saturation biopsies have been realized in our Service to 32 patients with high PSA, previous biopsies without diagnosis of prostate cancer and high suspicion of malignant disease. Results: The mean age was 65.81 years, with an average of previous biopsies of 2.41 (range: I to 5). Mean of PSA was 15.45 ng/dl (range: 5.63 to 35.47 ng/ml). The mean number of cores obtained in the saturation biopsies was of 20.78 (range: 16-26). 13 were diagnosed prostate adenocarcinomas (40.63 %), of which 10 had previous diagnosis of PIN or atipia. 8 patients underwent radical prostatectomy, 3 cases were treated with radiotherapy, I case was treated with hormonetherapy and the remaining one is kept in watchful waiting. Concordance of Gleason grade was in 6 of 8 patients treated surgically. Conclusions: Saturation biopsy is an effective method for the diagnosis of prostate cancer after several negative biopsies and a strong clinical suspicion of malignant pathology. Saturation biopsy is not a first choice procedure for the diagnosis of prostate cancer.
