Adipocytokines, Insulinresistance and Androgen Excess in Women

被引:0
|
作者
Georgescu, C. E. [1 ,2 ]
Goia-Socol, M. [1 ,2 ]
Marian, I [3 ,4 ]
Ilie, . R. [1 ,2 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Endocrinol, Cluj Napoca, Romania
[2] Cluj Cty Emergency Hosp, Endocrinol Clin, Cluj Napoca, Romania
[3] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Internal Med Cardiol 1, Cluj Napoca, Romania
[4] Cluj Cty Emergency Hosp, Clin Internal Med 1, Cluj Napoca, Romania
来源
PROCEEDINGS OF THE 49TH ANNUAL SCIENTIFIC MEETING OF THE EUROPEAN SOCIETY FOR CLINICAL INVESTIGATION | 2015年
关键词
Androgen excess; insulinresistance; adipocytokines; visceral fat; endothelial dysfunction; POLYCYSTIC-OVARY-SYNDROME; ENDOTHELIAL DYSFUNCTION; METABOLIC PHENOTYPE; ADIPONECTIN; OSTEOPROTEGERIN; PREVALENCE; ENDOCRINE; OBESITY; HYPERANDROGENEMIA; TESTOSTERONE;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Androgen excess (AE), the commonest endocrine disorder in women of reproductive age, has been recognized as a key risk factor for cardio-metabolic abnormalities. Dysfunctional visceral adipose tissue presumably intermediates deleterious effects of androgen hormones, to increase metabolic and vascular risk. High molecular weight (HMW)-adiponectin is selectively decreased in patients with the polycystic ovary syndrome (PCOS) and might act as independent biomarker of metabolic dysfunction, while visfatin, a pro-inflammatory cytokine, is related to AE and predicts endothelial dysfunction. As suggested by our work, the bone-pancreas endocrine loop might be involved through alterations in bone matrix undercarboxylated osteocalcin (ucOC) and osteoprotegerin (OPG) production as, in PCOS, both are associated with hyperandrogenemia and hyperinsulinism, and OPG also predicts vascular risk.
引用
收藏
页码:197 / 202
页数:6
相关论文
共 50 条
  • [1] Adipocytokines, insulinresistance and androgen excess in women.
    Georgescu, C. E.
    Goia-Socol, M.
    Marian, I.
    Ilie, I. R.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2015, 45 : 18 - 18
  • [2] Androgen excess in women
    Derman, RJ
    INTERNATIONAL JOURNAL OF FERTILITY AND MENOPAUSAL STUDIES, 1996, 41 (02) : 172 - 176
  • [3] ANDROGEN EXCESS IN WOMEN WITH ACNE
    SCHOLL, GM
    WU, CH
    LEYDEN, J
    OBSTETRICS AND GYNECOLOGY, 1984, 64 (05): : 683 - 688
  • [4] ANDROGEN EXCESS IN WOMEN WITH ACNE ALONE
    PESERICO, A
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1991, 96 (04) : 527 - 527
  • [5] Androgen excess in women - A health hazard?
    Rosmond, R
    MEDICAL HYPOTHESES, 2006, 67 (02) : 229 - 234
  • [6] The Role of Androgen Excess in Metabolic Dysfunction in Women Androgen Excess and Female Metabolic Dysfunction
    Escobar-Morreale, Hector F.
    SEX AND GENDER FACTORS AFFECTING METABOLIC HOMEOSTASIS, DIABETES AND OBESITY, 2017, 1043 : 597 - 608
  • [7] Clinical management of androgen excess and defect in women
    Rosato, Elena
    Sciarra, Francesca
    Minnetti, Marianna
    Degjoni, Anisa
    Venneri, Mary Anna
    EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, 2024, 19 (01) : 21 - 35
  • [8] Metabolic and cardiovascular issues in women with androgen excess
    Wild, RA
    ENDOCRINOLOGIST, 1996, 6 (02): : 120 - 124
  • [9] Androgen excess in women: Not just a cosmetic problem
    Dewailly, D.
    ANNALES D ENDOCRINOLOGIE, 2010, 71 (01) : 1 - 1
  • [10] Autonomic Dysfunction in Women with Androgen Excess PCOS
    Stone, Tori
    Leone, Cheryl
    Ayers, Thomas
    Stachenfeld, Nina
    FASEB JOURNAL, 2020, 34