The neurobiology of emotion regulation in posttraumatic stress disorder: Amygdala downregulation via real-time fMRI neurofeedback

被引：155

作者：

Nicholson, Andrew A. ^{[1
,2
,3
]}

Rabellino, Daniela ^{[2
,3
]}

Densmore, Maria ^{[3
]}

Frewen, Paul A. ^{[1
,4
]}

Paret, Christian ^{[5
,6
]}

Kluetsch, Rosemarie ^{[6
]}

Schmahl, Christian ^{[6
]}

Theberge, Jean ^{[2
,3
,7
,8
,9
]}

Neufeld, Richard W. J. ^{[1
,2
,4
]}

McKinnon, Margaret C. ^{[10
,11
,12
]}

Reiss, Jim ^{[2
]}

Jetly, Rakesh ^{[13
]}

Lanius, Ruth A. ^{[1
,2
,3
]}

机构：

[1] Univ Western Ontario, Dept Neurosci, London, ON, Canada

[2] Univ Western Ontario, Dept Psychiat, London, ON, Canada

[3] Lawson Hlth Res Inst, Dept Imaging, London, ON, Canada

[4] Univ Western Ontario, Dept Psychol, London, ON, Canada

[5] Heidelberg Univ, Fac Mannheim, Cent Inst Mental Hlth Mannheim, Dept Neuroimaging,Med, Heidelberg, Germany

[6] Heidelberg Univ, Cent Inst Mental Hlth Mannheim, Med Fac Mannheim, Dept Psychosomat Med & Psychotherapy, Heidelberg, Germany

[7] Univ Western Ontario, Dept Med Imaging, London, ON, Canada

[8] Univ Western Ontario, Dept Medial Biophys, London, ON, Canada

[9] St Josephs Healthcare, Dept Diagnost Imaging, London, ON, Canada

[10] St Josephs Healthcare, Mood Disorders Program, Hamilton, ON, Canada

[11] St Josephs Healthcare, Clin Neuropsychol Serv, Hamilton, ON, Canada

[12] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada

[13] Canadian Forces, Hlth Serv, Ottawa, ON, Canada

来源：

HUMAN BRAIN MAPPING | 2017年 / 38卷 / 01期

基金：

加拿大健康研究院;

关键词：

fMRI neurofeedback; posttraumatic stress disorder; amygdala; emotion; brain connectivity; RESTING-STATE CONNECTIVITY; FUNCTIONAL CONNECTIVITY; PREFRONTAL CORTEX; MODULATES AMYGDALA; INSULAR CORTEX; PTSD; FEAR; MODEL; METAANALYSIS; ANXIETY;

D O I：

10.1002/hbm.23402

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amygdala dysregulation has been shown to be central to the pathophysiology of posttraumatic stress disorder (PTSD) representing a critical treatment target. Here, amygdala downregulation was targeted using real-time fMRI neurofeedback (rt-fMRI-nf) in patients with PTSD, allowing us to examine further the regulation of emotional states during symptom provocation. Patients (n=10) completed three sessions of rt-fMRI-nf with the instruction to downregulate activation in the amygdala, while viewing personalized trauma words. Amygdala downregulation was assessed by contrasting (a) regulate trials, with (b) viewing trauma words and not attempting to regulate. Training was followed by one transfer run not involving neurofeedback. Generalized psychophysiological interaction (gPPI) and dynamic causal modeling (DCM) analyses were also computed to explore task-based functional connectivity and causal structure, respectively. It was found that PTSD patients were able to successfully downregulate both right and left amygdala activation, showing sustained effects within the transfer run. Increased activation in the dorsolateral and ventrolateral prefrontal cortex (PFC), regions related to emotion regulation, was observed during regulate as compared with view conditions. Importantly, activation in the PFC, rostral anterior cingulate cortex, and the insula, were negatively correlated to PTSD dissociative symptoms in the transfer run. Increased functional connectivity between the amygdala- and both the dorsolateral and dorsomedial PFC was found during regulate, as compared with view conditions during neurofeedback training. Finally, our DCM analysis exploring directional structure suggested that amygdala downregulation involves both top-down and bottom-up information flow with regard to observed PFC-amygdala connectivity. This is the first demonstration of successful downregulation of the amygdala using rt-fMRI-nf in PTSD, which was critically sustained in a subsequent transfer run without neurofeedback, and corresponded to increased connectivity with prefrontal regions involved in emotion regulation during the intervention. Hum Brain Mapp 38:541-560, 2017. (c) 2016 Wiley Periodicals, Inc.

引用

页码：541 / 560

页数：20

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