Microwave-assisted synthesis of deuterium labeled estrogen fatty acid esters

被引：15

作者：

Kiuru, PS ^{[1
]}

Wähälä, K ^{[1
]}

机构：

[1] Univ Helsinki, Organ Chem Lab, Dept Chem, FIN-00014 Helsinki, Finland

来源：

STEROIDS | 2006年 / 71卷 / 01期

关键词：

estrogen; synthesis; fatty acid ester; deuteration; microwave;

D O I：

10.1016/j.steroids.2005.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deuterated analogs of estrogen fatty acid esters are needed as internal standards for isotope dilution GC/MS analyses. We have developed a rapid and efficient synthesis for 2,4,16,16-D-4-estrone palmitate, stearate, oleate, linoleate, and linolenate and the corresponding 2,4,16,16,17(alpha-D-5-estradiol fatty acid 17-mono and 3,17-diesters using analogous fatty acid chlorides or fatty acid anhydrides and 4-(dimethylamino)pyridine under microwave irradiation. Chemoselective hydrolysis of fatty acid diesters was carried out by KOH in t-BuOH. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：54 / 60

页数：7

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