ADIPOQ polymorphisms are associated with insulin resistance in Japanese women

被引：7

作者：

Kitamoto, Aya ^{[1
]}

Kitamoto, Takuya ^{[1
]}

So, Rina ^{[2
]}

Matsuo, Tomoaki ^{[2
]}

Nakata, Yoshio ^{[2
]}

Hyogo, Hideyuki ^{[3
]}

Ochi, Hidenori ^{[3
]}

Nakamura, Takahiro ^{[4
]}

Kamohara, Seika ^{[5
]}

Miyatake, Nobuyuki ^{[6
]}

Kotani, Kazuaki ^{[7
]}

Mineo, Ikuo ^{[8
]}

Wada, Jun ^{[9
]}

Ogawa, Yuji ^{[10
]}

Yoneda, Masato ^{[10
]}

Nakajima, Atsushi ^{[10
]}

Funahashi, Tohru ^{[11
]}

Miyazaki, Shigeru ^{[12
]}

Tokunaga, Katsuto ^{[13
]}

Masuzaki, Hiroaki ^{[14
]}

Ueno, Takato ^{[15
]}

Chayama, Kazuaki ^{[3
]}

Hamaguchi, Kazayuki ^{[16
]}

Yamada, Kentaro ^{[17
]}

Hanafusa, Toshiaki ^{[18
]}

Oikawa, Shinichi ^{[19
]}

Sakata, Toshiie ^{[20
]}

Tanaka, Kiyoji ^{[2
]}

Matsuzawa, Yuji ^{[7
]}

Hotta, Kikuko ^{[1
]}

机构：

[1] Kyoto Univ, Pharmacogen, Grad Sch Med, Kyoto 6068501, Japan

[2] Univ Tsukuba, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058574, Japan

[3] Hiroshima Univ, Dept Gastroenterol & Metab, Inst Biomed & Hlth Sci, Hiroshima 7348551, Japan

[4] Natl Def Med Coll, Math Lab, Tokorozawa, Saitama 3598513, Japan

[5] Hlth Sci Univ, Minamitsuru, Yamanashi 4010380, Japan

[6] Kagawa Univ, Dept Hyg, Fac Med, Kagawa 7610793, Japan

[7] Osaka Univ, Dept Metab Med, Grad Sch Med, Suita, Osaka 5650871, Japan

[8] Otemae Hosp, Osaka 5400008, Japan

[9] Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008558, Japan

[10] Yokohama City Univ, Sch Med, Dept Gastroenterol & Hepatol, Yokohama, Kanagawa 2360004, Japan

[11] Osaka Univ, Dept Metab & Atherosclerosis, Grad Sch Med, Suita, Osaka 5650871, Japan

[12] Tokyo Postal Serv Agcy Hosp, Tokyo 1028798, Japan

[13] Itami City Hosp, Itami, Hyogo 6648540, Japan

[14] Univ Ryukyus, Div Endocrinol Diabet & Metab, Hematol, Rheumatol Grad Sch Med, Nishihara, Okinawa 9030215, Japan

[15] Kurume Univ, Res Ctr Innovat Canc Therapy, Kurume, Fukuoka 8300011, Japan

[16] Oita Univ, Dept Pract Nursing Sci, Fac Med, Oita 8795593, Japan

[17] Kurume Univ, Div Endocrinol & Metab, Dept Med, Kurume, Fukuoka 8300011, Japan

[18] Osaka Med Coll, Dept Internal Med 1, Takatsuki, Osaka 5698686, Japan

[19] Fukujuji Hosp, Diabet & Lifestyle Dis Ctr, Tokyo 2048522, Japan

[20] Oita Univ, Dept Internal Med 1, Fac Med, Oita 8795593, Japan

来源：

ENDOCRINE JOURNAL | 2015年 / 62卷 / 06期

关键词：

ADIPOQ; Single nucleotide polymorphism; Visceral adipose tissue; Insulin resistance; Adiponectin; GENOME-WIDE ASSOCIATION; BODY-FAT DISTRIBUTION; ADIPONECTIN LEVELS; VISCERAL FAT; GENES; METAANALYSIS; PHENOTYPES; VARIANTS; PROTEIN; LOCI;

D O I：

10.1507/endocrj.EJ14-0574

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Visceral fat accumulation contributes to the development of insulin resistance, leading to metabolic syndrome. Adiponectin provides a link between visceral fat accumulation and insulin resistance. In addition to environmental factors, genetic factors play important roles in visceral fat accumulation and circulating adiponectin levels. Genome-wide association studies (GWASs) have identified genetic variations in the adiponectin, C1Q and collagen domain containing (ADIPOQ) gene that are associated with adiponectin levels. In this study, we investigated whether ADIPOQ single nucleotide polymorphisms (SNPs) were associated with visceral fat accumulation and insulin resistance. We measured the visceral fat area (VFA) by computed tomography (CT) and examined the presence of the insulin resistance-related phenotype (fasting plasma glucose, fasting insulin, and homeostasis model assessment-insulin resistance [HOMA-IR]) in a set of Japanese individuals (731 men and 864 women) who were genotyped for seven ADIPOQ SNPs reported by recent GWASs (namely, rs6810075, rs10937273, rs1648707, rs864265, rs182052, rs17366568, and rs6773957). SNPs associated with the phenotype (P < 0.05) were then evaluated by association analysis using a second set of the study participants (383 men and 510 women). None of the SNPs was associated with body mass index (BMI) or VFA in men or women. However, the adiponectin-decreasing alleles of rs10937273 and rs1648707 were significantly associated with HOMA-IR (P = 0.0030 and P = 0.00074, respectively) in women, independently of BMI. These SNPs were significantly associated with decreased adiponectin levels in women. Our results suggested that rs10937273 and rs1648707 may affect insulin sensitivity by regulating adiponectin production by adipose tissue in women.

引用

页码：513 / 521

页数：9

共 30 条

[1] Association between ADIPOQ SNPs with plasma adiponectin and glucose homeostasis and adiposity phenotypes in the IRAS Family Study [J].

An, S. Sandy ;

Hanley, Anthony J. G. ;

Ziegler, Julie T. ;

Brown, W. Mark ;

Haffner, Steven M. ;

Norris, Jill M. ;

Rotter, Jerome I. ;

Guo, Xiuqing ;

Chen, Y. -D. Ida ;

Wagenknecht, Lynne E. ;

Langefeld, Carl D. ;

Bowden, Donald W. ;

Palmer, Nicholette D. .

MOLECULAR GENETICS AND METABOLISM, 2012, 107 (04) :721-728

[2] Intra-abdominal fat is a major determinant of the national cholesterol education program adult treatment panel III criteria for the metabolic syndrome [J].

Carr, DB ;

Utzschneider, KM ;

Hull, RL ;

Kodama, K ;

Retzlaff, BM ;

Brunzell, JD ;

Shofer, JB ;

Fish, BE ;

Knopp, RH ;

Kahn, SE .

DIABETES, 2004, 53 (08) :2087-2094

[3] Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals [J].

Dastani, Zari ;

Hivert, Marie-France ;

Timpson, Nicholas ;

Perry, John R. B. ;

Yuan, Xin ;

Scott, Robert A. ;

Henneman, Peter ;

Heid, Iris M. ;

Kizer, Jorge R. ;

Lyytikainen, Leo-Pekka ;

Fuchsberger, Christian ;

Tanaka, Toshiko ;

Morris, Andrew P. ;

Small, Kerrin ;

Isaacs, Aaron ;

Beekman, Marian ;

Coassin, Stefan ;

Lohman, Kurt ;

Qi, Lu ;

Kanoni, Stavroula ;

Pankow, James S. ;

Uh, Hae-Won ;

Wu, Ying ;

Bidulescu, Aurelian ;

Rasmussen-Torvik, Laura J. ;

Greenwood, Celia M. T. ;

Ladouceur, Martin ;

Grimsby, Jonna ;

Manning, Alisa K. ;

Liu, Ching-Ti ;

Kooner, Jaspal ;

Mooser, Vincent E. ;

Vollenweider, Peter ;

Kapur, Karen A. ;

Chambers, John ;

Wareham, Nicholas J. ;

Langenberg, Claudia ;

Frants, Rune ;

Willems-vanDijk, Ko ;

Oostra, Ben A. ;

Willems, Sara M. ;

Lamina, Claudia ;

Winkler, Thomas W. ;

Psaty, Bruce M. ;

Tracy, Russell P. ;

Brody, Jennifer ;

Chen, Ida ;

Viikari, Jorma ;

Kahonen, Mika ;

Pramstaller, Peter P. .

PLOS GENETICS, 2012, 8 (03)

[4] Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women [J].

Fox, Caroline S. ;

Liu, Yongmei ;

White, Charles C. ;

Feitosa, Mary ;

Smith, Albert V. ;

Heard-Costa, Nancy ;

Lohman, Kurt ;

Johnson, Andrew D. ;

Foster, Meredith C. ;

Greenawalt, Danielle M. ;

Griffin, Paula ;

Ding, Jinghong ;

Newman, Anne B. ;

Tylavsky, Fran ;

Miljkovic, Iva ;

Kritchevsky, Stephen B. ;

Launer, Lenore ;

Garcia, Melissa ;

Eiriksdottir, Gudny ;

Carr, J. Jeffrey ;

Gudnason, Vilmunder ;

Harris, Tamara B. ;

Cupples, L. Adrienne ;

Borecki, Ingrid B. .

PLOS GENETICS, 2012, 8 (05)

[5] Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: Results of genome-wide association analyses including 4659 European individuals [J].

Heid, Iris M. ;

Henneman, Peter ;

Hicks, Andrew ;

Coassin, Stefan ;

Winkler, Thomas ;

Aulchenko, Yurii S. ;

Fuchsberger, Christian ;

Song, Kijoung ;

Hivert, Marie-France ;

Waterworth, Dawn M. ;

Timpson, Nicholas J. ;

Richards, J. Brent ;

Perry, John R. B. ;

Tanaka, Toshiko ;

Amin, Najaf ;

Kollerits, Barbara ;

Pichler, Irene ;

Oostra, Ben A. ;

Thorand, Barbara ;

Frants, Rune R. ;

Illig, Thomas ;

Dupuis, Josee ;

Glaser, Beate ;

Spector, Tim ;

Guralnik, Jack ;

Egan, Josephine M. ;

Florez, Jose C. ;

Evans, David M. ;

Soranzo, Nicole ;

Bandinelli, Stefania ;

Carlson, Olga D. ;

Frayling, Timothy M. ;

Burling, Keith ;

Smith, George Davey ;

Mooser, Vincent ;

Ferrucci, Luigi ;

Meigs, James B. ;

Vollenweider, Peter ;

van Dijk, Ko Willems ;

Pramstaller, Peter ;

Kronenberg, Florian ;

van Duijn, Cornelia M. .

ATHEROSCLEROSIS, 2010, 208 (02) :412-420

[6] Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys [J].

Hotta, K ;

Funahashi, T ;

Bodkin, NL ;

Ortmeyer, HK ;

Arita, Y ;

Hansen, BC ;

Matsuzawa, Y .

DIABETES, 2001, 50 (05) :1126-1133

[7] Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients [J].

Hotta, K ;

Funahashi, T ;

Arita, Y ;

Takahashi, M ;

Matsuda, M ;

Okamoto, Y ;

Iwahashi, H ;

Kuriyama, H ;

Ouchi, N ;

Maeda, K ;

Nishida, M ;

Kihara, S ;

Sakai, N ;

Nakajima, T ;

Hasegawa, K ;

Muraguchi, M ;

Ohmoto, Y ;

Nakamura, T ;

Yamashita, S ;

Hanafusa, T ;

Matsuzawa, Y .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (06) :1595-1599

[8] Replication Study of 15 Recently Published Loci for Body Fat Distribution in the Japanese Population [J].

Hotta, Kikuko ;

Kitamoto, Aya ;

Kitamoto, Takuya ;

Mizusawa, Seiho ;

Teranishi, Hajime ;

So, Rina ;

Matsuo, Tomoaki ;

Nakata, Yoshio ;

Hyogo, Hideyuki ;

Ochi, Hidenori ;

Nakamura, Takahiro ;

Kamohara, Seika ;

Miyatake, Nobuyuki ;

Kotani, Kazuaki ;

Itoh, Naoto ;

Mineo, Ikuo ;

Wada, Jun ;

Yoneda, Masato ;

Nakajima, Atsushi ;

Funahashi, Tohru ;

Miyazaki, Shigeru ;

Tokunaga, Katsuto ;

Masuzaki, Hiroaki ;

Ueno, Takato ;

Chayama, Kazuaki ;

Hamaguchi, Kazuyuki ;

Yamada, Kentaro ;

Hanafusa, Toshiaki ;

Oikawa, Shinichi ;

Sakata, Toshiie ;

Tanaka, Kiyoji ;

Matsuzawa, Yuji ;

Nakao, Kazuwa ;

Sekine, Akihiro .

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2013, 20 (04) :336-350

[9] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography [J].

Hotta, Kikuko ;

Kitamoto, Aya ;

Kitamoto, Takuya ;

Mizusawa, Seiho ;

Teranishi, Hajime ;

So, Rina ;

Matsuo, Tomoaki ;

Nakata, Yoshio ;

Hyogo, Hideyuki ;

Ochi, Hidenori ;

Nakamura, Takahiro ;

Kamohara, Seika ;

Miyatake, Nobuyuki ;

Kotani, Kazuaki ;

Komatsu, Ryoya ;

Itoh, Naoto ;

Mineo, Ikuo ;

Wada, Jun ;

Yoneda, Masato ;

Nakajima, Atsushi ;

Funahashi, Tohru ;

Miyazaki, Shigeru ;

Tokunaga, Katsuto ;

Masuzaki, Hiroaki ;

Ueno, Takato ;

Chayama, Kazuaki ;

Hamaguchi, Kazuyuki ;

Yamada, Kentaro ;

Hanafusa, Toshiaki ;

Oikawa, Shinichi ;

Yoshimatsu, Hironobu ;

Sakata, Toshiie ;

Tanaka, Kiyoji ;

Matsuzawa, Yuji ;

Nakao, Kazuwa ;

Sekine, Akihiro .

JOURNAL OF HUMAN GENETICS, 2012, 57 (05) :305-310

[10] Genetic variations in the CYP17A1 and NT5C2 genes are associated with a reduction in visceral and subcutaneous fat areas in Japanese women [J].

Hotta, Kikuko ;

Kitamoto, Aya ;

Kitamoto, Takuya ;

Mizusawa, Seiho ;

Teranishi, Hajime ;

Matsuo, Tomoaki ;

Nakata, Yoshio ;

Hyogo, Hideyuki ;

Ochi, Hidenori ;

Nakamura, Takahiro ;

Kamohara, Seika ;

Miyatake, Nobuyuki ;

Kotani, Kazuaki ;

Komatsu, Ryoya ;

Itoh, Naoto ;

Mineo, Ikuo ;

Wada, Jun ;

Yoneda, Masato ;

Nakajima, Atsushi ;

Funahashi, Tohru ;

Miyazaki, Shigeru ;

Tokunaga, Katsuto ;

Masuzaki, Hiroaki ;

Ueno, Takato ;

Chayama, Kazuaki ;

Hamaguchi, Kazuyuki ;

Yamada, Kentaro ;

Hanafusa, Toshiaki ;

Oikawa, Shinichi ;

Yoshimatsu, Hironobu ;

Sakata, Toshiie ;

Tanaka, Kiyoji ;

Matsuzawa, Yuji ;

Nakao, Kazuwa ;

Sekine, Akihiro .

JOURNAL OF HUMAN GENETICS, 2012, 57 (01) :46-51

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