A modular approach to prepare enantioenriched cyclobutanes: synthesis of (+)-rumphellaone A

被引：47

作者：

Beck, Jordan C. ^{[1
]}

Lacker, Caitlin R. ^{[1
]}

Chapman, Lauren M. ^{[1
]}

Reisman, Sarah E. ^{[1
]}

机构：

[1] CALTECH, Warren & Katharine Schlinger Lab Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

CHEMICAL SCIENCE | 2019年 / 10卷 / 08期

关键词：

N-HYDROXYPHTHALIMIDE ESTERS; ENANTIOSELECTIVE SYNTHESIS; CARBOXYLIC-ACIDS; NATURAL-PRODUCT; ARYLATION; DERIVATIVES; CATALYSIS; RUMPHELLAONE; ACTIVATION; ALKYLATION;

D O I：

10.1039/c8sc05444d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A modular synthesis of enantioenriched polyfunctionalized cyclobutanes was developed that features an 8aminoquinolinamide directed C-H arylation reaction. The C-H arylation products were derivatized through subsequent decarboxylative coupling processes. This synthetic strategy enabled a 9-step enantioselective total synthesis of the antiproliferative meroterpenoid (+)-rumphellaone A.

引用

页码：2315 / 2319

页数：5

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