Cannabinoid modulation of subgenual anterior cingulate cortex activation during experience of negative affect

被引：19

作者：

Rabinak, Christine A. ^{[1
,2
]}

Sripada, Chandra Sekhar ^{[1
]}

Angstadt, Mike ^{[1
]}

de Wit, Harriet ^{[3
]}

Phan, K. Luan ^{[1
,2
,4
]}

机构：

[1] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[2] Vet Affairs Ann Arbor Healthcare Syst, Mental Hlth Serv, Ann Arbor, MI 48105 USA

[3] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA

[4] Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF NEURAL TRANSMISSION | 2012年 / 119卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Cannabinoid; Amygdala; Subgenual anterior cingulate; Emotion; fMRI; SITU HYBRIDIZATION HISTOCHEMISTRY; ENDOCANNABINOID SYSTEM; MESSENGER-RNA; HUMAN BRAIN; MOOD; RECEPTOR; AMYGDALA; EMOTION; DELTA(9)-TETRAHYDROCANNABINOL; DEPRESSION;

D O I：

10.1007/s00702-011-0747-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cannabinoids affect positive and negative affective experience and emotional perception, possibly by modulating limbic brain reactivity. In this double-blind crossover, placebo-controlled functional magnetic resonance imaging study in humans, an acute oral dose of Delta(9)-tetrahydrocannabinol (THC) attenuated subgenual anterior cingulate cortex (sgACC) reactivity during the induction of negative affect. This observation extends prior findings implicating a cortico-limbic, emotion-related central mechanism underlying cannabinoid function.

引用

页码：701 / 707

页数：7

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