KL-6, a human MUC1 mucin, promotes proliferation and survival of lung fibroblasts

被引：90

作者：

Ohshimo, S ^{[1
]}

Yokoyama, A ^{[1
]}

Hattori, N ^{[1
]}

Ishikawa, N ^{[1
]}

Hirasawa, Y ^{[1
]}

Kohno, N ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Biomed Sci, Dept Mol & Internal Med, Div Clin Med Sci,Programs Appl Biomed, Hiroshima, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 04期

关键词：

interstitial lung disease; idiopathic pulmonary fibrosis; therapeutic agent; apoptosis;

D O I：

10.1016/j.bbrc.2005.10.144

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The serum level of KL-6, a MUC1 mucin, is a clinically useful marker for various interstitial lung diseases. Previous studies demonstrated that KL-6 promotes chemotaxis of human fibroblasts. However, the pathophysiological role of KL-6 remains poorly understood. Here, we further investigate the functional aspects of KL-6 in proliferation and apoptosis of lung fibroblasts. KL-6 accelerated the proliferation and inhibited the apoptosis of all human lung fibroblasts examined. An anti-KL-6 monoclonal antibody counteracted both of these effects induced by KL-6 on human lung fibroblasts. The pro-fibroproliferative and anti-apoptotic effects of KL-6 are greater than and additive to those of the maximum effective concentrations of platelet-derived growth factor, basic fibroblast growth factor, and transforming growth factor-beta. These findings indicate that increased levels of KL-6 in the epithelial lining fluid may stimulate fibrotic processes in interstitial lung diseases and raise the possibility of applying an anti-KL-6 antibody to treat interstitial lung diseases. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1845 / 1852

页数：8

共 35 条

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