99mTc-labeled 1-thio-β-D-glucose as a new tumor-seeking agent:: Synthesis and tumor cell uptake assay

被引：28
作者：
Oh, SJ
Ryu, JS
Yoon, EJ
Bae, MS
Choi, SJ
Park, KB
Moon, DH
机构：
[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Nucl Med, Seoul 138736, South Korea
[2] Ewha Womans Univ, Mokdong Hosp, Dept Radiol, Div Nucl Med, Seoul, South Korea
[3] Hanaro Ctr, Korea Atom Energy Res Inst, Div Radioisotope Prod & Applicat, Taejon 305600, South Korea
来源：
APPLIED RADIATION AND ISOTOPES | 2006年 / 64卷 / 02期
关键词：
Tc-99m; 1-thio-beta-D-glucose; tumor imaging; glucose derivatives; tumor cell uptake assay;
D O I：
10.1016/j.apradiso.2005.07.022
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Tc-99m-labeled 1-thio-beta-D-glucose (Tc-99m-1-TG) was synthesized under different ligand concentrations. 1-Thio-beta-D-glucose (1-TG) showed different chemical properties and higher stability at acid pH as compared to neutral and basic pH. Under different ligand concentrations, Tc-99m-1-TG was obtained with high labeling efficiency of > 97%, but the HPLC chromatogram varied with the ligand concentration. The results of a tumor cell uptake assay also depended on the ligand concentration. With the lowest ligand concentration tested (0.5 mg/ml of 1-TG), we obtained the highest uptake. With different glucose and insulin concentrations, Tc-99m-1-TG uptake was not significantly different from that of [F-18]FDG. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：207 / 215
页数：9
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