Over-the-counter medications: Risk and safety in pregnancy

被引：12

作者：

Chambers, Christina ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Pediat, Div Dysmorphol & Teratol, La Jolla, CA 92093 USA

来源：

SEMINARS IN PERINATOLOGY | 2015年 / 39卷 / 07期

关键词：

over-the-counter medications; drug safety; pregnancy; PRENATAL EXPOSURE; ACETAMINOPHEN USE; TERATOGENICITY; EMBRYOPATHY; COHORT;

D O I：

10.1053/j.semperi.2015.08.009

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Over-the-counter (OTC) medications are among the most commonly used products in pregnancy. Similar to prescription medications, for many products there is a lack of adequate data on safety of use in pregnancy. Assumptions of safety for these products based on long experience and OTC status, in the absence of data, may be ill founded. Examples of four OTC products used to treat common conditions in pregnancy are described. Potential links to adverse short- and long-term infant outcomes for these products are reviewed, and the strengths and limitations of data to support these. Research to detect or rule out these risks is essential. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：541 / 544

页数：4

共 19 条

[1] Evolving Knowledge of the Teratogenicity of Medications in Human Pregnancy [J].

Adam, Margaret P. ;

Polifka, Janine E. ;

Friedman, J. M. .

AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS, 2011, 157C (03) :175-182

[2] Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled cohort study [J].

Brandlistuen, Ragnhild Eek ;

Ystrom, Eivind ;

Nulman, Irena ;

Koren, Gideon ;

Nordeng, Hedvig .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2013, 42 (06) :1702-1713

[3] BENDECTIN - REVIEW OF THE MEDICAL LITERATURE OF A COMPREHENSIVELY STUDIED HUMAN NONTERATOGEN AND THE MOST PREVALENT TORTOGEN-LITIGEN [J].

BRENT, RL .

REPRODUCTIVE TOXICOLOGY, 1995, 9 (04) :337-349

[4] Antenatal Acetaminophen Use and Attention-Deficit/Hyperactivity Disorder An Interesting Observed Association But Too Early to Infer Causality [J].

Cooper, Miriam ;

Langley, Kate ;

Thapar, Anita .

JAMA PEDIATRICS, 2014, 168 (04) :306-307

[5] Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis [J].

Eyers, S. ;

Weatherall, M. ;

Jefferies, S. ;

Beasley, R. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2011, 41 (04) :482-489

[6]

Food and Nutrition Board Institute of Medicine, 2001, DIET REF INT VIT A V

[7] Prenatal Exposure to Acetaminophen and Asthma in Children [J].

Kang, Elizabeth M. ;

Lundsberg, Lisbet S. ;

Illuzzi, Jessica L. ;

Bracken, Michael B. .

OBSTETRICS AND GYNECOLOGY, 2009, 114 (06) :1295-1306

[8] RETINOIC ACID EMBRYOPATHY [J].

LAMMER, EJ ;

CHEN, DT ;

HOAR, RM ;

AGNISH, ND ;

BENKE, PJ ;

BRAUN, JT ;

CURRY, CJ ;

FERNHOFF, PM ;

GRIX, AW ;

LOTT, IT ;

RICHARD, JM ;

SUN, SC .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (14) :837-841

[9] Acetaminophen Use During Pregnancy, Behavioral Problems, and Hyperkinetic Disorders [J].

Liew, Zeyan ;

Ritz, Beate ;

Rebordosa, Cristina ;

Lee, Pei-Chen ;

Olsen, Jorn .

JAMA PEDIATRICS, 2014, 168 (04) :313-320

[10] Paracetamol overdose in pregnancy analysis of the outcomes of 300 cases referred to the teratology information service [J].

McElhatton, PR ;

Sullivan, FM ;

Volans, GN .

REPRODUCTIVE TOXICOLOGY, 1997, 11 (01) :85-94

← 1 2 →