Tau protein hyperphosphorylation in sporadic ALS with cognitive impairment

被引：46

作者：

Strong, MJ

Yang, W

Strong, WL

Leystra-Lantz, C

Jaffe, H

Pant, HC

机构：

[1] Robarts Res Inst, Cell Biol Res Grp, London, ON N6A 5C1, Canada

[2] Univ Western Ontario, Schulich Sch Med, Dept Clin Neurol Sci, London, ON N6A 3K7, Canada

[3] NINDS, NIH, Bethesda, MD 20892 USA

来源：

NEUROLOGY | 2006年 / 66卷 / 11期

关键词：

D O I：

10.1212/01.wnl.0000218161.15834.db

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors have characterized frontal cortical tau protein in cognitively intact ( 4) and cognitively impaired (ALSci, 4) ALS patients and compared it with control ( 2) or Alzheimer disease (AD,1)- derived tau. The authors observed expression of both 3R and 4R tau isoforms; increased insoluble tau protein; phosphatase resistance; and hyperphosphorylation at T175, S208, and S210. Soluble tau from both AD and ALSci was also phosphorylated at S237. Tau hyperphosphorylation is associated with ALS.

引用

收藏

页码：1770 / 1771

页数：2

相关论文

共 10 条

[1] Are amyotrophic lateral sclerosis patients cognitively normal? [J].

Lomen-Hoerth, C ;

Murphy, J ;

Langmore, S ;

Kramer, JH ;

Olney, RK ;

Miller, B .

NEUROLOGY, 2003, 60 (07) :1094-1097

[2] NEW PATHOLOGICAL FINDINGS IN AMYOTROPHIC-LATERAL-SCLEROSIS [J].

LOWE, J .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1994, 124 :38-51

[3] Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias [J].

Mott, RT ;

Dickson, DW ;

Trojanowski, JQ ;

Zhukareva, V ;

Lee, VM ;

Forman, M ;

Van Deerlin, V ;

Ervin, JF ;

Wang, DS ;

Schmechel, DE ;

Hulette, CM .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2005, 64 (05) :420-428

[4] Frontotemporal lobar degeneration - A consensus on clinical diagnostic criteria [J].

Neary, D ;

Snowden, JS ;

Gustafson, L ;

Passant, U ;

Stuss, D ;

Black, S ;

Freedman, M ;

Kertesz, A ;

Robert, PH ;

Albert, M ;

Boone, K ;

Miller, BL ;

Cummings, J ;

Benson, DF .

NEUROLOGY, 1998, 51 (06) :1546-1554

[5]

Noda K, 1999, CLIN NEUROPATHOL, V18, P218

[6] Cognitive impairment, frontotemporal dementia, and the motor neuron diseases [J].

Strong, MJ ;

Lomen-Hoerth, C ;

Caselli, RJ ;

Bigio, EH ;

Yang, W .

ANNALS OF NEUROLOGY, 2003, 54 :S20-S23

[7] Cognitive impairment in sporadic ALS - A pathologic continuum underlying a multisystem disorder [J].

Wilson, CM ;

Grace, GM ;

Munoz, DG ;

He, BP ;

Strong, MJ .

NEUROLOGY, 2001, 57 (04) :651-657

[8] Microtubule-associated tau protein positive neuronal and glial inclusions in ALS [J].

Yang, WC ;

Sopper, MM ;

Leystra-Lantz, C ;

Strong, MJ .

NEUROLOGY, 2003, 61 (12) :1766-1773

[9] Tau protein aggregation in the frontal and entorhinal cortices as a function of aging [J].

Yang, WC ;

Ang, LC ;

Strong, MJ .

DEVELOPMENTAL BRAIN RESEARCH, 2005, 156 (02) :127-138

[10] Amyotrophic lateral sclerosis with dementia: The clinicopathological spectrum [J].

Yoshida, M .

NEUROPATHOLOGY, 2004, 24 (01) :87-102