Complete genomic sequence of the goat prion protein gene (PRNP)

被引：3
作者：
Van Poucke, Mario [1 ]
Willemarck, Nicolas [1 ]
Hugot, Karine [2 ]
Van Zeveren, Alex [1 ]
Peelman, Luc J. [1 ]
机构：
[1] Univ Ghent, Fac Vet Med, Dept Nutr Genet & Ethol, B-9820 Merelbeke, Belgium
[2] INRA, CRB GADIE, Lab Radiobiol & Etude Genome, F-78352 Jouy En Josas, France
来源：
VIRUS GENES | 2009年 / 38卷 / 01期
关键词：
Goat; Prion protein; Genomic sequence; TSE; BOVINE SPONGIFORM ENCEPHALOPATHY; CAPRINE PRP GENE; POLYMORPHISMS; SHEEP; SCRAPIE; BSE; IDENTIFICATION; VARIABILITY; EXPRESSION; REGIONS;
D O I：
10.1007/s11262-008-0288-z
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Prion protein genetics plays a central role in transmissible spongiform encephalopathies, a disease occurring in human and animals. Here we report a 27-kb genomic sequence containing the goat PRNP gene. It shows, both in structure and content, a remarkable similarity with its sheep ortholog and can serve as a basis for future (comparative) studies with reference to the regulation of PRNP gene expression and the search for genetic tools to prevent/control/eradicate (goat) TSE.
引用
收藏
页码：189 / 192
页数：4
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