Complete genomic sequence of the goat prion protein gene (PRNP)

被引：3

作者：

Van Poucke, Mario ^{[1
]}

Willemarck, Nicolas ^{[1
]}

Hugot, Karine ^{[2
]}

Van Zeveren, Alex ^{[1
]}

Peelman, Luc J. ^{[1
]}

机构：

[1] Univ Ghent, Fac Vet Med, Dept Nutr Genet & Ethol, B-9820 Merelbeke, Belgium

[2] INRA, CRB GADIE, Lab Radiobiol & Etude Genome, F-78352 Jouy En Josas, France

来源：

VIRUS GENES | 2009年 / 38卷 / 01期

关键词：

Goat; Prion protein; Genomic sequence; TSE; BOVINE SPONGIFORM ENCEPHALOPATHY; CAPRINE PRP GENE; POLYMORPHISMS; SHEEP; SCRAPIE; BSE; IDENTIFICATION; VARIABILITY; EXPRESSION; REGIONS;

D O I：

10.1007/s11262-008-0288-z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Prion protein genetics plays a central role in transmissible spongiform encephalopathies, a disease occurring in human and animals. Here we report a 27-kb genomic sequence containing the goat PRNP gene. It shows, both in structure and content, a remarkable similarity with its sheep ortholog and can serve as a basis for future (comparative) studies with reference to the regulation of PRNP gene expression and the search for genetic tools to prevent/control/eradicate (goat) TSE.

引用

页码：189 / 192

页数：4

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