A New Wave of Amide Bond Formations for Peptide Synthesis

被引：42

作者：

Hollanders, Karlijn ^{[1
,2
]}

Maes, Bert U. W. ^{[2
]}

Ballet, Steven ^{[1
]}

机构：

[1] Vrije Univ Brussel, Res Grp Organ Chem, Pl Laan 2, B-1050 Brussels, Belgium

[2] Univ Antwerp, Organ Synth, Dept Chem, Groenenborgerlaan 171, B-2020 Antwerp, Belgium

来源：

SYNTHESIS-STUTTGART | 2019年 / 51卷 / 11期

关键词：

amides; peptides; amino acids; non-classical peptide couplings; carboxylic acid surrogates; amine surrogates; NONACTIVATED CARBOXYLIC-ACIDS; HYDROXYLAMINE KAHA LIGATIONS; CHEMICAL PROTEIN-SYNTHESIS; DIRECT AMIDATION; AMINO-ACID; COUPLING-REAGENT; PHASE SYNTHESIS; ALPHA; THIOACIDS; ESTERIFICATION;

D O I：

10.1055/s-0037-1611773

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The construction of peptidic amide bonds has become a daily laboratory practice by virtue of well-established coupling reagents'. Nonetheless, inherent limitations connected to these classical coupling methods in terms of waste, safety and expense have yet to be conquered. Research efforts have been devoted to synthetic methods able to surpass these limitations. This short review focuses on the advances made in these non-classical' methods for amide bond formation with a specific application in peptide chemistry. It consists of two main sections: (i) novel carboxylic activation reagents, and (ii) carboxylic acid and amine surrogates. 1 Introduction 2 Alternative Carboxylic acid Activation Reagents 3 Carboxylic Acid and Amine Surrogates 4 Conclusion and Perspectives

引用

页码：2261 / 2277

页数：17

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