On-line monitoring of the distillates of a solvent switch process by near-infrared spectroscopy

被引：8
作者：
Ge, ZH
Buchanan, B
Timmermans, J
De Tora, D
Ellison, D
Wyvratt, J
机构：
[1] Merck Res Labs, Analyt Res Dept, Rahway, NJ 07065 USA
[2] Sensors 2 Informat, Elkton, VA 22827 USA
[3] Merck Mfg Div, Regulatory & Analyt Sci Proc Analyt, W Point, PA 19486 USA
来源：
PROCESS CONTROL AND QUALITY | 1999年 / 11卷 / 04期
关键词：
near-infrared spectroscopy; on-line process monitoring; alcohol; temperature variation;
D O I：
10.1163/156856699750249404
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
An on-line fiber-optic near-infrared spectroscopic method has been developed for real-time monitoring of distillate composition as a reliable way of assessing the degree of a solvent switch process from methanol and n-propanol to isopropyl acetate. Multivariate statistical methods of Multiple Linear Regression and Partial Least Squares were evaluated for quantitative determination of the total alcohol concentrations in the distillate samples. Robust models were obtained by incorporating temperature variance into the calibration set. Reliable prediction of total alcohol concentration was successfully achieved by near-infrared spectroscopy as judged by a comparison with gas chromatography data.
引用
收藏
页码：277 / 287
页数：11
相关论文
共 18 条
  • [1] HIGHLY DIASTEREOSELECTIVE REACTION OF A CHIRAL, NON-RACEMIC AMIDE ENOLATE WITH (S)-GLYCIDYL TOSYLATE - SYNTHESIS OF THE ORALLY-ACTIVE HIV-1 PROTEASE INHIBITOR L-735,524
    ASKIN, D
    ENG, KK
    ROSSEN, K
    PURICK, RM
    WELLS, KM
    VOLANTE, RP
    REIDER, PJ
    [J]. TETRAHEDRON LETTERS, 1994, 35 (05) : 673 - 676
  • [2] AN INTRODUCTION TO MULTIVARIATE CALIBRATION AND ANALYSIS
    BEEBE, KR
    KOWALSKI, BR
    [J]. ANALYTICAL CHEMISTRY, 1987, 59 (17) : A1007 - +
  • [3] NEAR-INFRARED STUDIES OF STRUCTURE OF WATER .1. PURE WATER
    BUIJS, K
    CHOPPIN, GR
    [J]. JOURNAL OF CHEMICAL PHYSICS, 1963, 39 (08) : 2035 - &
  • [4] USES OF NEAR-INFRARED SPECTROSCOPY IN PHARMACEUTICAL ANALYSIS
    CIURCZAK, EW
    [J]. APPLIED SPECTROSCOPY REVIEWS, 1987, 23 (1-2) : 147 - 163
  • [5] CURTIN D, 1997, J P ANAL CHEM, V1, P18
  • [6] Influence and correction of temperature perturbations on NIR spectra during the monitoring of a polymorph conversion process prior to self-modelling mixture analysis
    DeBraekeleer, K
    Sanchez, FC
    Hailey, PA
    Sharp, DCA
    Pettman, AJ
    Massart, DL
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1998, 17 (01) : 141 - 152
  • [7] L-735,524 - THE DESIGN OF A POTENT AND ORALLY BIOAVAILABLE HIV PROTEASE INHIBITOR
    DORSEY, BD
    LEVIN, RB
    MCDANIEL, SL
    VACCA, JP
    GUARE, JP
    DARKE, PL
    ZUGAY, JA
    EMINI, EA
    SCHLEIF, WA
    QUINTERO, JC
    LIN, JH
    CHEN, IW
    HOLLOWAY, MK
    FITZGERALD, PMD
    AXEL, MG
    OSTOVIC, D
    ANDERSON, PS
    HUFF, JR
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (21) : 3443 - 3451
  • [8] HYDROGEN BOND SYSTEMS - TEMPERATURE DEPENDENCE OF OH FREQUENCY SHIFTS AND OH BAND INTENSITIES
    FINCH, JN
    LIPPINCOTT, ER
    [J]. JOURNAL OF PHYSICAL CHEMISTRY, 1957, 61 (07) : 894 - 902
  • [9] PARTIAL LEAST-SQUARES REGRESSION - A TUTORIAL
    GELADI, P
    KOWALSKI, BR
    [J]. ANALYTICA CHIMICA ACTA, 1986, 185 : 1 - 17
  • [10] PARTIAL LEAST-SQUARES METHODS FOR SPECTRAL ANALYSES .1. RELATION TO OTHER QUANTITATIVE CALIBRATION METHODS AND THE EXTRACTION OF QUALITATIVE INFORMATION
    HAALAND, DM
    THOMAS, EV
    [J]. ANALYTICAL CHEMISTRY, 1988, 60 (11) : 1193 - 1202
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