Chiral azole derivatives, 3.: Synthesis of the enantiomers of the potent aromatase inhibitor 1-[2-benzofuranyl(4-chlorophenyl)methyl]-1H-imidazole

被引：13

作者：

Messina, F ^{[1
]}

Botta, M ^{[1
]}

Corelli, F ^{[1
]}

Mugnaini, C ^{[1
]}

机构：

[1] Univ Siena, Dipartimento Farmaco Chim Technol, Branchi di Sotto, I-53100 Siena, Italy

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 40期

关键词：

asymmetric synthesis; annulation; benzofurans; antitumour compounds;

D O I：

10.1016/S0040-4039(99)01569-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from (+)- and (-)-1-(4-chlorophenyl)-2-propynylamine, in turn obtained by CAL-mediated kinetic resolution of the corresponding racemate, a stereoselective synthesis of both enantiomers of the title compound has been achieved. (C) 1999 Published by Elsevier Science Ltd, All rights reserved.

引用

页码：7289 / 7292

页数：4

共 21 条

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