The role of intrinsic excitability in the evolution of memory: Significance in memory allocation, consolidation, and updating

被引：39

作者：

Chen, Lingxuan ^{[1
]}

Cummings, Kirstie A. ^{[1
]}

Mau, William ^{[1
]}

Zaki, Yosif ^{[1
]}

Dong, Zhe ^{[1
]}

Rabinowitz, Sima ^{[1
]}

Clem, Roger L. ^{[1
]}

Shuman, Tristan ^{[1
]}

Cai, Denise J. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2020年 / 173卷

关键词：

Intrinsic excitability; Synaptic plasticity; Memory allocation; Memory consolidation; Memory updating; Temporal memory-linking; LONG-TERM POTENTIATION; CA1 PYRAMIDAL NEURONS; CALCIUM-DEPENDENT AFTERHYPERPOLARIZATION; EXCITATORY SYNAPTIC-TRANSMISSION; CA2+-ACTIVATED K+ CHANNELS; WHOLE-CELL RECORDINGS; AFTER-HYPERPOLARIZATION; SK CHANNELS; OPTICAL ELECTROPHYSIOLOGY; TRANSCRIPTION FACTORS;

D O I：

10.1016/j.nlm.2020.107266

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Memory is a dynamic process that is continuously regulated by both synaptic and intrinsic neural mechanisms. While numerous studies have shown that synaptic plasticity is important in various types and phases of learning and memory, neuronal intrinsic excitability has received relatively less attention, especially regarding the dynamic nature of memory. In this review, we present evidence demonstrating the importance of intrinsic excitability in memory allocation, consolidation, and updating. We also consider the intricate interaction between intrinsic excitability and synaptic plasticity in shaping memory, supporting both memory stability and flexibility.

引用

页数：12

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